Abstract
The study is aimed at creating nanostructured coatings based on hexagonal boron nitride with a high sorption capacity with respect to various therapeutic drugs and prolonged antibacterial effect due to gradual release into the physiological environment. The coatings were obtained via interaction of gaseous ammonia with a precursor of amorphous boron nanoparticles. The antibiotics gentamicin sulfate and ciprofloxacin and the antifungal drug amphotericin B were used as bactericides. The release kinetics of the antibiotics were assayed for different pH values. Antibacterial studies showed that all types of coatings are bactericidal to the antibiotic-resistant strain Escherichia coli K-261. Coatings saturated with amphotericin B showed antifungal activity against various ascomycete strains Neurospora crassa wild type wt-987 and nitrogen metabolism mutants nit-2 and nit-6.
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Funding
The study was supported by the Russian Science Foundation (contract 20-19-00120), as well as by the Ministry of Education and Science of the Russian Federation (NUST MISIS Competitiveness Enhancement Program no. K2A-2018-038) for IR spectroscopy studies (K.Yu. Gudz).
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Gudz, K.Y., Permyakova, E.S., Matveev, A.T. et al. Desorption Properties and Bactericidal and Fungicidal Activity of Nanostructured Coatings Based on Hexagonal Boron Nitride Saturated with Therapeutic Preparations. Nanotechnol Russia 15, 445–450 (2020). https://doi.org/10.1134/S1995078020040047
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DOI: https://doi.org/10.1134/S1995078020040047