Abstract
In the present study, pure titanium (Ti) plates were firstly treated to form various types of oxide layers on the surface and then were immersed into simulated body fluid (SBF) to evaluate the apatite-forming ability. The surface morphology and roughness of the different oxide layers were measured by atomic force microscopy (AFM), and the surface energies were determined based on the Owens–Wendt (OW) methods. It was found that Ti samples after alkali heat (AH) treatment achieved the best apatite formation after soaking in SBF for three weeks, compared with those without treatment, thermal or H2O2 oxidation. Furthermore, contact angle measurement revealed that the oxide layer on the alkali heat treated Ti samples possessed the highest surface energy. The results indicate that the apatite-inducing ability of a titanium oxide layer links to its surface energy. Apatite nucleation is easier on a surface with a higher surface energy.
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T. Kokubo, F. Miyaji H.M. Kim: Spontaneous formation of bonelike apatite layer on chemically treated titanium metals. J. Am. Ceram. Soc. 79, 1127 1996
A. Moroni, V.L. Caja, E.L. Egger, L. Trinchese E.Y.S. Chao: Histomorphometry of hydroxyapatite coated and uncoated porous titanium bone implants. Biomaterials 15, 926 1994
C.E. Wen, W. Xu, W.Y. Hu P.D. Hodgson: Hydroxyapatite/titania sol-gel coatings on titanium-zirconium alloy for biomedical applications. Acta Biomater. 3, 403 2007
W. Xu, W.Y. Hu, M.H. Li, Q.Q. Ma, P.D. Hodgson C.E. Wen: Sol-gel derived HA/TiO2 double coatings on Ti scaffolds for orthopaedic applications. Trans. Nonferrous Met. Soc. China 16, s209 2006
W. Xu, W.Y. Hu, M. Li C.E. Wen: Sol-gel derived hydroxyapatite/titania biocoatings on titanium substrate. Mater. Lett. 60, 1575 2006
L.H. Li, Y.M. Kong, H.W. Kim, Y.W. Kim, H.E. Kim, S.J. Heo J.Y. Koak: Improved biological performance of Ti implants due to surface modification by micro-arc oxidation. Biomaterials 25, 2867 2004
M. Uchida, H.M. Kim, T. Kokubo, S. Fujibayashi T. Nakamura: Effect of water treatment on the apatite-forming ability of NaOH-treated titanium metal. J. Biomed. Mater. Res. 63, 522 2002
H.M. Kim, T. Kokubo, S. Fujibayashi, S. Nishiguchi T. Nakamura: Bioactive macroporous titanium surface layer on titanium substrate. J. Biomed. Mater. Res. 52, 553 2000
L. Jonasova, F.A. Muller, A. Helebrant, J. Strnad P. Greil: Hydroxyapatite formation on alkali-treated titanium with different content of Na+ in the surface. Biomaterials 23, 3095 2002
S.J. Li, R. Yang, M. Niinomi, Y.L. Hao Y.Y. Cui: Formation and growth of calcium phosphate on the surface of oxidized Ti–29Nb–13Ta–4.6Zr alloy. Biomaterials 25, 2525 2004
T. Kokubo, H.M. Kim M. Kawashita: Novel bioactive materials with different mechanical properties. Biomaterials 24, 2161 2003
H. Takadama, H.M. Kim, T. Kokubo T. Nakamura: XPS study of the process of apatite formation on bioactive Ti–6Al–4V alloy in simulated body fluid. Sci. Tech. Adv. Mater. 2, 389 2001
R. Rohanizadeh, M.A. Sadeq R.Z. Legeros: Preparation of different forms of titanium oxide on titanium surface: Effects on apatite deposition. J. Biomed. Mater. Res. A 71, 343 2004
X.B. Chen, A. Nouri, P.D. Hodgson C.E. Wen: Surface modification of TiZr alloy for biomedical application. Adv. Mater. Res. 15–17, 89 2007
C.E. Wen, Y. Yamada, K. Shimojima, Y. Chino, H. Hosokawa M. Mabuchi: Novel titanium foam for bone tissue engineering. J. Mater. Res. 17, 2633 2002
X.X. Wang, S. Hayakawa, K. Tsuru A. Osaka: A comparative study of in vitro apatite deposition on heat-, H2O2- and NaOH-treated titanium surfaces. J. Biomed. Mater. Res. 54, 172 2001
M. Kosmulski: The significance of the difference in the point of zero charge between rutile and anatase. Adv. Colloid Interface Sci. 99, 255 2002
H.M. Kim, T. Himeno, M. Kawashita, J.H. Lee, T. Kokubo T. Nakamura: Surface potential change in bioactive titanium metal during the process of apatite formation in simulated body fluid. J. Biomed. Mater. Res. A 67, 1305 2003
M. Uchida, H.M. Kim, T. Kokubo, S. Fujibayashi T. Nakamura: Structural dependence of apatite formation on titania gels in a simulated body fluid. J. Biomed. Mater. Res. A 64, 164 2003
X.X. Wang, S. Hayakawa, K. Tsuru A. Osaka: Bioactive titania gel layers formed by chemical treatment of Ti substrate with a H2O2/HCl solution. Biomaterials 23, 1353 2002
J.M. Wu, J.F. Liu, S. Hayakawa, K. Tsuru A. Osaka: Low-temperature deposition of rutile film on biomaterials substrates and its ability to induce apatite deposition in vitro. J. Mater. Sci. Mater. Med. 18, 1529 2007
T. Peltola, M. Patsi, H. Rahiala, I. Kangasniemi A. Yli-Urpo: Calcium phosphate induction by sol-gel-derived titania coatings on titanium substrates in vitro. J. Biomed. Mater. Res. 41, 504 1998
D.V. Kilpadi J.E. Lemons: Surface energy characterization of unalloyed titanium implants. J. Biomed. Mater. Res. 28, 1419 1994
D.V. Kilpadi, J.J. Weimer J.E. Lemons: Effect of passivation and dry heat-sterilization on surface energy and topography of unalloyed titanium implants. Colloids Surf. A 135, 89 1998
D.V. Kilpadi, G.N. Raikar, J. Liu, J.E. Lemons, Y. Vohra J.C. Gregory: Effect of surface treatment on unalloyed titanium implants: Spectroscopic analyses. J. Biomed. Mater. Res. 40, 646 1998
G. Zhao, Z. Schwartz, M. Wieland, F. Rupp, J.G. Gerstorfer, D.L. Cochran B.D. Boyan: High surface energy enhances cell response to titanium substrate microstructure. J. Biomed. Mater. Res. A 74, 49 2005
G. Altankov, F. Grinnell T. Groth: Studies on the biocompatibility of materials: Fibroblast reorganization of substratum-bound fibronectin on surfaces varying in wettability. J. Biomed. Mater. Res. 30, 385 1996
X. Lu, Z. Zhao Y. Leng: Biomimetic calcium phosphate coatings on nitric-acid-treated titanium surfaces. Mater. Sci. Eng., C 27, 700 2007
A. Oyane, K. Onuma, A. Ito, H.M. Kim, T. Kokubo T. Nakamura: Formation and growth of clusters in conventional and new kinds of simulated body fluids. J. Biomed. Mater. Res. A 64, 339 2003
Z. Zhong, S. Yin, C. Liu, Y. Zhong, W. Zhang, D. Shi C.A. Wang: Surface energy for electroluminescent polymers and indium–tin–oxide. Appl. Surf. Sci. 207, 183 2003
M. Takemoto, S. Fujibayashi, M. Neo, J. Suzuki, T. Matsushita, T. Kokubo T. Nakamura: Osteoinductive porous titanium implants: Effect of sodium removal by dilute HCl treatment. Biomaterials 27, 2682 2006
D.V. Bavykin, J.M. Friedrich F.C. Walsh: Protonated titanates and TiO2 nanostructured materials: Synthesis, properties, and applications. Adv. Mater. 18, 2807 2006
R.N. Wenzel: Resistance of solid surfaces to wetting by water. Ind. Eng. Chem. 28, 988 1936
I.V. Markov: Crystal Growth for Beginners: Fundamentals of Nucleation, Crystal Growth, and Epitaxy World Science Singapore 1995 77
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The authors acknowledge the financial support for this research through the ARC Discovery Project DP0770021 (Australian Research Council). P. Hodgson is also supported by the ARC through a Federation Fellowship.
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Wang, X., Li, Y., Lin, J. et al. Apatite-inducing ability of titanium oxide layer on titanium surface: The effect of surface energy. Journal of Materials Research 23, 1682–1688 (2008). https://doi.org/10.1557/JMR.2008.0195
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DOI: https://doi.org/10.1557/JMR.2008.0195