Abstract
Considerations from control theory revealed that an elevated gain of the feedback loop may lead to instability of the respiratory system, e.g. during sleep [Longobardo et al.,1982; Honda et al., 1983; Khoo, 2000; Dempsey et al., 2004]. In respiratory medicine, the carbonic anhydrase (CA) inhibitor acetazolamide is known to reduce the incidence of apneas in mountain sickness [Swenson et al., 1991]or sleep disordered breathing [Tojima et al., 1988; Verbraecken et al., 1998]. Other clinical studies revealed that patients prone to sleep apnea showed an increased sodium/proton exchange activity in their lymphocytes [Tepel et al., 2000]. To predict possible protective effects of substances inhibiting either carbonic anhydrase activity or sodium/proton exchange, we evaluated steady state feedback loop characteristics of the respiratory control system from previous studies in anaesthetized rabbits [Kiwull-Schöne et al., 2001a,b]. Steady state loop gain (G) was assessed as ratio of the slope of the CO2 response (S) and that of the metabolic hyperbola (SL ) [Honda et al., 1983; Khoo, 2000] at the intersection of both curves, by which also the arterial set point PCO2 (PspCO2) is determined.
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References
Dempsey JA, Smith CA, Przybylowski T, Chenuel B, Xie A, Nakayama H, Skatrud JB. The ventilatory responsiveness to CO2 below eupnoea as a determinant of ventilatory stability in sleep. J Physiol 2004, 560: 1–11.
Honda Y, Hayashi F, Yoshida A, Ohyabu Y, Nishibayashi Y, Kimura H. Overall “gain” of the respiratory control system in normoxic humans awake and asleep. J Appl Physiol 1983, 55: 1530–1535.
Khoo MCK. Determinants of ventilatory instability and variability. Respir Physiol 2000, 122: 167–182.
Kiwull-Schöne H, Kiwull P. Effectiveness of the peripheral chemoreflex control system in the adjustment of arterial O2 pressure and O2-Hb saturation. Adv Exp Med Biol 1997, 428: 433–438.
Kiwull-Schöne HF, Teppema LJ, Kiwull PJ. Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits. Am J Resp Crit Care Med 2001a, 163: 478–483.
Kiwull-Schöne H, Wiemann M, Frede S, Bingmann D, Wirth KJ, Heinelt U, Lang H-J, Kiwull P. A novel inhibitor of the Na+/H+ exchanger type 3 activates the central respiratory CO2 response and lowers the apneic threshold. Am J Resp Crit Care Med 2001b, 164: 1303–1311.
Longobardo GS, Gothe B, Goldman MD, Cherniack NS. Sleep apnea considered as a control system instability. Respir Physiol 1982, 50: 311–333.
Swenson ER, Leatham KL, Roach RC, Schoene RB, Mills WJ, Hackett PH. Renal carbonic anhydrase inhibition reduces high altitude sleep periodic breathing. Respir Physiol 1991, 86: 333–343.
Tepel M, Sanner BM, Van der Giet M, Zidek W. Increased sodium-proton antiporter activity in patients with obstructive sleep apnea. J Sleep Res 2000, 9: 285–291.
Tojima H, Kunitomo F, Kimura H, Tatsumi K, Kuriyama T, Honda Y. Effects of acetazolamide in patients with the sleep apnea syndrome. Thorax 1988, 43: 113–119.
Verbraecken J, Willemen M, De Cock W, Coen E, Van de Heyning P, De Backer W. Central sleep apnea after interrupting longterm acetazolamide therapy. Respir Physiol 1998, 112: 59–70.
Wiemann M, Frede S, Bingmann D, Kiwull P, Kiwull-Schöne H. Sodium/proton exchanger 3 in the medulla oblongata and set point of breathing control. Am J Resp Crit Care Med 2005 (in press)
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KIWULL-SCHÖNE, H., TEPPEMA, L., WIEMANN, M., KIWULL, P. (2006). Loop Gain of Respiratory Control upon Reduced Activity of Carbonic Anhydrase or Na+/H+ Exchange. In: Hayashida, Y., Gonzalez, C., Kondo, H. (eds) THE ARTERIAL CHEMORECEPTORS. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 580. Springer, Boston, MA. https://doi.org/10.1007/0-387-31311-7_37
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DOI: https://doi.org/10.1007/0-387-31311-7_37
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