Abstract
We have shown on several occasions that the pressure response to a small-amplitude volume change (both sinusoids and steps) in the constantly activated heart is identical to the force response to a small-amplitude length change in constantly activated cardiac muscle (3–9). One pattern of dynamic responses in both preparations implies that the mechanisms responsible for small-amplitude mechanodynamics in the intact heart are the same as those responsible for mechanodynamics in muscle. The common underlying mechanism in both preparations is the interaction between the thick and thin myofilaments via cycling crossbridges. Thus, it is possible to observe crossbridge dynamics in the intact heart just as in isolated muscle preparations of a few sarcomeres.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Campbell KB. Time scale and oscillatory features of left ventricular step response originate from multiple-step crossbridge cycle. In: Ingels NB Jr, Daughters GT, Baan J, Covell JW, Reneman RS, and Yin FC-P, eds. Systolic and Diastolic Function of the Heart. Amsterdam, IOS Press and Ohmsha, 1995:249–255.
Campbell KB. Rate constant of muscle force re-development reflects cooperative activation as well as crossbridge kinetics. Biophys J. 1997;72:254–262.
Campbell KB, Rahimi AR, Bell DL, Kirkpatrick RD, Ringo JA. Pressure response to quick volume changes in the tetanized, isolated ferret heart. Am J Physiol. 1989;251 (Heart Circ Physiol. 26):H38-H46.
Campbell KB, Taheri H, Kirkpatrick RD, Burton T, Hunter WC. Similarities between dynamic elastance of left ventricular chamber and papillary muscle of rabbit heart. Am J Physiol. 1993;264 (Heart Circ Physiol. 33):H1926-H1941.
Campbell KB, Shroff SG, Kirkpatrick RD. Short time-scale LV systolic dynamics: Evidence for a common mechanism in both LV chamber and heart-muscle mechanics. Circ Res. 1991;68:1532–1548.
Campbell KB, Campbell LW, Pinto JE, Burton TD. Contractile-based model interpretation of pressure-volume dynamics in the constantly activated (Ba2+) isolated heart. Ann Biomed Eng. 1994;22:550–567.
Campbell KB, Kirkpatrick RD, Tobias AH, Taheri H, Shroff SG. Series-coupled noncontractile elements are functionally unimportant in the isolated heart. Cardiovasc Res. 1994;28:242–251.
Shroff SG, Campbell KB, Kirkpatrick RD. Short time-scale LV systolic dynamics: Pressure vs. flow clamps and effects of activation. Am J Physiol. 1993; 264 (Heart Circ Physiol. 33):H946-H959.
ter Keurs HEDJ, Campbell KB, Mulier JP, Gwathmey J, Burkhoff D, Glantz SA, Arts T, Baan J, Hunter WC, Kass D, Ingels NB Jr, Sys SU. From crossbridge to myocardium to intact heart. In: Ingels NB Jr, Daughters GT, Baan J, Covell JW, Reneman RS, Yin FC-P, eds. Systolic and Diastolic Function of the Heart. Amsterdam, IOS Press and Ohmsha, 1995:227–238.
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Campbell, K.B., Kirkpatrick, R.D. (1998). Crossbridge Cycling and Cooperative Recruitment Can Account for Oscillatory Dynamics of Constantly Activated Heart. In: Analysis and Assessment of Cardiovascular Function. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1744-2_4
Download citation
DOI: https://doi.org/10.1007/978-1-4612-1744-2_4
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7261-8
Online ISBN: 978-1-4612-1744-2
eBook Packages: Springer Book Archive