Skip to main content

New-Age Rapid Diagnosis of Acute Myocardial Injury

  • Chapter
Analysis and Assessment of Cardiovascular Function
  • 115 Accesses

Abstract

The complications associated with heart disease inevitably progress toward heart failure. This occurs either when the heart fails to pump blood at a rate required or when the heart can do so only with an elevated filling pressure. It has been estimated that two million individuals in the United States are currently undergoing treatment for heart failure, and that 400,000 new cases occur annually. According to a recent American Heart Association report, about 1.5 million Americans suffer acute myocardial infarction (AMI) each year (1). Among the two thirds who survive an event of myocardial infarction, two thirds do not make a full recovery. The single most significant disease in terms of both mortality and morbidity, AMI accounts for one half of the nearly one million deaths each year by cardiovascular disease in patients who have had noncardiac surgery. In the United States, the economic burden of coronary artery disease (CAD) is estimated at $50 to 100 billion per year in medical interventions and lost wages (10,21).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. American Heart Association. Heart and Stroke Facts: 1996 Statistical Supplement Dallas: American Heart Association; 1996:1–23.

    Google Scholar 

  2. Adams JE III, Abendschein DR, Jaffe AS. Biochemical markers of myocardial injury: Is MB creatine kinase the choice for the 1990s? Circulation. 1993;88:750.

    Article  PubMed  CAS  Google Scholar 

  3. Apple FS. Glycogen phosphorylase BB and other cardiac proteins: Challenges to creatine kinase MB as the marker for detecting myocardial injury. Clin Chem. 1995;41:966–978.

    Google Scholar 

  4. Bluestein BI, Walczak IM, Chen S. Fiber optic evanescent wave immunosensor for medical diagnostics. TIBTECH. 1990;8:161.

    Article  CAS  Google Scholar 

  5. Bodor GS, Porterfield D, Voss EN, Smith S, Apple FS. Cardiac troponin-I is not expressed in fetal and healthy or diseased adult human skeletal muscle tissue. Clin Chem. 1995;41:1710.

    PubMed  CAS  Google Scholar 

  6. Braunwald E. Control of myocardial oxygen consumption: Physiologic and clinical considerations. Am J Cardiol 1971;27:416.

    Article  PubMed  CAS  Google Scholar 

  7. Braunwald E. ed. Heart Disease: A Textbook of Cardiovascular Medicine. 5th edition. WB Saunder; 1997.

    Google Scholar 

  8. Buda AJ, Zotz RJ, Pace DP, Krause LC. Comparison of two-dimensional echocardiographic wall motion and wall thickening abnormalities in relation to the myocardium at risk. Am Heart J. 1986;111:587.

    Article  PubMed  CAS  Google Scholar 

  9. Cummins P, Young A, Auckland ML, Michie CA, Stone PCW, Shepstone BJ. Comparison of serum cardiac specific troponin-I with creatine kinase, creatine kinase-MB isoenzyme, tropomysin, myoglobin, and C-reactive protein release in marathon runners: Cardiac or skeletal muscle trauma? Ear J Clin Invest. 1987;17:317.

    Article  CAS  Google Scholar 

  10. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA. 1993;269:3015.

    Google Scholar 

  11. Feigenbaum H. Echocardiography. In: Braunwald E, ed. Heart Disease. A Textbook of Cardiovascular Medicine. 5th edition. WB Saunders; 1997.

    Google Scholar 

  12. Fisch C. Evolution of the clinical electrocardiogram. J Am Coll Cardiol. 1989;14:1127.

    Article  PubMed  CAS  Google Scholar 

  13. Johnson CL, Rifkind BM, Sempos CT, Carroll MD, Bachorik PS, Briefel RR, Gordon DJ, Burt VZ, Brown CD, Lippel K, Cleeman J. Declining serum total cholesterol levesl among US adults: The National Health and Nutrition Examination Surveys. JAMA. 1993;269:3002.

    Article  PubMed  CAS  Google Scholar 

  14. Johnson JR, DiPalma JR. Intramyocardial pressure and its relation to aortic blood pressure. Am J Physiol 1939;125:234.

    Google Scholar 

  15. Juronen EI, Viikmaa MH, Mikelsaar AN. Rapid simple and sensitive antigen capture ELISA for the quantitation of myoglobin using monoclonal antibodies. J Immunol Methods. 1988;111:109.

    Article  PubMed  CAS  Google Scholar 

  16. Konings CH, Funke Kupper AJ, Verbeugt FWA. Comparison of two latex agglutination test kits for serum myoglobin in the exclusion of acute myocardial infarction. Ann Clin Biochem. 1989;26:254.

    PubMed  Google Scholar 

  17. Kresh JY, Brockman SK, Cobanoglu MA, Goldman SM. Continuous intraoperative monitoring of myocardial tissue pressure: Experimental and clinical results. Surg Forum. 1985;36:301.

    Google Scholar 

  18. Kricka LJ. Selected strategies for improving sensitivity and reliability of immu-noassays. Clin Chem. 1994;40:347.

    PubMed  CAS  Google Scholar 

  19. Lowe CR. An introduction to the concepts and technology of biosensors. Biosensors. 1985;1:3.

    Article  PubMed  CAS  Google Scholar 

  20. Ligler FS, Rabbany SY. Biological microstructures in biosensors. In: Schnur JM, Peckerar M, eds. Synthetic Microstructures in Biological Research. New York: Plenum, 67, 1992.

    Google Scholar 

  21. National Cholesterol Education Program. Second report of the expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel II). Circulation. 1994;89:1329.

    Google Scholar 

  22. Mair J, Wagner I, Morass B, Fridrich L, Lechleitner P, Dienstl F, Calzolari C, Larue C, Puschendorf B. Cardiac troponin I release correlates with myocardial infarction size. Eur J Clin Chem Clin Biochem. 1995;33:869.

    PubMed  CAS  Google Scholar 

  23. Murphy DA, Armour JA. Human cardiac nerve stimulation. Ann Thorac Surg. 1992;54:502.

    Article  PubMed  CAS  Google Scholar 

  24. Porter WT. The influence of the heart-beat on the flow of blood through the walls of the heart. Am J Physiol. 1898;1:145.

    Google Scholar 

  25. Rabbany SY. The Genesis of Intramyocardial Pressure. Philadelphia: University of Pennsylvania. Available from Ann Arbor J MI: University Microfilms; 1991. Dissertation.

    Google Scholar 

  26. Rabbany SY, Donner BL, Ligler FS. Optical immunosensors. Crit Rev Biomed Eng. 1994;22:307.

    PubMed  CAS  Google Scholar 

  27. Rabbany SY, Kresh JY, Noordergraaf A. Intramyocardial prssure: Interaction of myocardial fluid pressure and fiber stress. Am J Physiol. 1989;257:H357.

    Google Scholar 

  28. Rabbany SY, Kusterbeck AW, Bredehorst R, Ligler FS. Effect of antibody density on the displacement kinetics of flow immunoassay. J Immunol Methods. 1994;168:227.

    Article  PubMed  CAS  Google Scholar 

  29. Rabban SY, Kusterbeck AW, Bredhorst R, Ligler FS. Binding kinetics of immobilized antibodies in a flow immunosensor. Sensors Actuators. 1995;29:72.

    Article  Google Scholar 

  30. Roberts R. Enzymatic estimation of infarct size: Thrombolysis induced its demise. Will it now rekindle its renaissance? Circulation. 1990;81:707.

    Article  PubMed  CAS  Google Scholar 

  31. Scaramucci GB. Diario Parmeuse. 1689. Cited by Von Haller, A: Element a Physiologiae Corporis Humani. Lausanne, Switzerland. Sumptibus Marci-Michael, Bousquet et sociorum 1778;4:459.

    Google Scholar 

  32. Thompson RJ, Jackson AP, Langolis N. Circulating antibodies to mouse monoclonal immunoglobulins in normal subjects: Incidence, species specificity, and effects of a two-site assay for creatine kinase-MB isoenzyme. Clin Chem. 1986;32:476.

    PubMed  CAS  Google Scholar 

  33. Tsung JS, Tsung SS. Creatine kinase isoenzymes in extracts of various human skeletal muscles. Clin Chem. 1986;32:1568.

    PubMed  CAS  Google Scholar 

  34. Vaidya HC, Beatty BG. Eliminating interference from heterophilic antibodies in a two-site immunoassay for creatine kinase MB by using F(ab’)2 conjugate and polyclonal mouse IgG. Clin Chem. 1992;38:1737.

    PubMed  CAS  Google Scholar 

  35. Wilkinson JM, Grand RJA. Comparison of amino acid sequence of troponin I from different striated muscle. Nature. 1978;271:31.

    Article  PubMed  CAS  Google Scholar 

  36. Zaninotto M, Altinier S, Lachin M, Carraro P, Mario P. Fluoroenzymometric method to measure cardiac troponin I in sera of patients with myocardial infarction. Clin Chem. 1996;42:1460.

    PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Rabbany, S.Y. (1998). New-Age Rapid Diagnosis of Acute Myocardial Injury. In: Analysis and Assessment of Cardiovascular Function. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1744-2_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1744-2_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7261-8

  • Online ISBN: 978-1-4612-1744-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics