Abstract
RG, a 60-year-old African-American man, presents to your clinic with a 6-week history of fatigue and right hip pain, which he attributes to a fall a few months ago. He has not seen a physician in years because he has felt well. However, he did visit the ER a week ago for his hip pain and labs showed a creatinine of 1.9 mg/dL. He has been taking 800–1,200 mg of ibuprofen daily for the last 2 weeks. His physical examination is notable for pain over the right hip. Laboratory studies show a creatinine of 4.6 mg/dL, calcium of 11 mg/dL, and hemoglobin of 7.2 g/dL. Plain films of the right hip show osteolytic lesions. Urine dipstick is negative for protein.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kyle RA. Multiple myeloma: an odyssey of discovery. Br J Haematol. 2000;111:1035–44.
Kyle RA, Rajkumar SV. Multiple myeloma. Blood. 2008;111:2962–72.
Clamp JR. Some aspects of the first recorded case of multiple myeloma. Lancet. 1967;290:1354–6.
Korngold L, Lipari R. Multiple-myeloma III. The antigenic relationship of BenceJones proteins to normal gammaglobulin and multiple-myeloma serum proteins. Cancer. 1956;9:262–72.
International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2003;121(5):749–57.
Herrara G. Renal lesions associated with plasma cell dyscrasias, practical approach to diagnosis, new concepts and challenges. Arch Pathol Lab Med. 2009;133:240–67.
Korbet SM, Schwartz MM. Multiple myeloma. J Am Soc Nephrol. 2006;17:2533–45.
Kyle RA, Rajkumar SV. Multiple myeloma. N Engl J Med. 2004;351:1860–73.
Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003;78:21–33.
Lin J, Markowitz GS, Valeri AM, et al. Renal monoclonal immunoglobulin deposition disease: the disease spectrum. J Am Soc Nephrol. 2001;12:1482–92.
Greipp PR, San Miguel J, Durie BG, et al. International staging system for multiple myeloma. J Clin Oncol. 2005;23(15):3412.
Kyle RA, Therneau TM, Rajkumar SV. Incidence of multiple myeloma in Olmsted County, Minnesota: trend over 6 decades. Cancer. 2004;101:2667–74.
US Renal Data System: USRDS 2005 annual data report: atlas of end-stage renal disease in the United States. Bethesda, MD: National Institutes of Health, National Institute Diabetes and Digestive and Kidney Diseases; 2005.
Dimopoulos MA, Terpos E, Chanan-Khan A. Renal impairment in patients with multiple myeloma: a consensus statement on behalf of the international myeloma working group. J Clin Oncol. 2010;29:4976–84.
Christensen EI, Brin H. Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule. Am J Physiol Renal Physiol. 2001;280:F562–73.
Batuman V. Proximal tubular injury in myeloma. In: Herrera GA, editor. The kidney in plasma cell dyscrasias, Contribution to nephrology, vol. 153. Basel: Karger; 2007. p. 87–104.
Solomon A, Weiss DT, Kattine AA. Nephrotoxic potential of Bence Jones proteins. N Engl J Med. 1991;324:1845–51.
Monteseny JJ, Kleinknecht D, Meyrier A, et al. Long-term outcome according to renal histological lesions in 118 patients with monoclonal gammopathies. Nephrol Dial Transplant. 1998;13:1438–45.
Basnayake K, Ying WZ, Wang PX, et al. Immunoglobulin light chains activate tubular epithelial cells through redox signaling. J Am Soc Nephrol. 2010;21:1165–73.
Merlini G, Pozzi C. Mechanisms of renal damage in plasma cell dyscrasias: an overview. In: Herrera GA, editor. The kidney in plasma cell dyscrasias, Contribution to nephrology, vol. 153. Basel: Karger; 2007. p. 66–86.
Keeling J, Herrera GA. The mesangium as a target for glomerulopathic light and heavy chains: pathogenic considerations in light and heavy chain-mediated glomerular damage. In: Herrera GA, editor. The kidney in plasma cell dyscrasias, Contribution to nephrology, vol. 153. Basel: Karger; 2007. p. 116–34.
Ronco P, Plaisier E, Mougenot B. Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy. Clin J Am Soc Nephrol. 2006;1:1342–50.
Keeling J, Teng J, Herrera GA. AL-amyloidosis and light chain deposition disease light chains induce divergent phenotypic transformations of human mesangial cells. Lab Invest. 2004;84:1322–38.
Westermark P, Benson MD, Buxbaum JN. Amyloid: toward terminology clarification. Amyloid. 2005;12:1–4.
Falk RH, Skinner M. The systemic amyloidoses: an overview. Adv Intern Med. 2000;45:107–37.
Herrera GA. Renal manifestations of plasma cell dyscrasias: an appraisal from the patient’s bedside to the research laboratory. Ann Diagn Pathol. 2000;4:174–200.
Dember LM. Light chains, casts, sheets and fibrils: monoclonal immunoglobulin diseases and immunotactoid/fibrillaryglomerulopathy. Clin J Am Soc Nephrol. 2006;1:1320–1.
Ganeval D, Noël LH, Preud’homme JL, et al. Light-chain deposition disease: its relation with AL-type amyloidosis. Kidney Int. 1984;26(1):1.
Korbet SM, Schwartz MM, Lewis EJ. Immunotactoidglomerulopathy (fibrillary glomerulonephritis). Clin J Am Soc Nephrol. 2006;1:1351–6.
Alpers CE, Kowalewska J. Fibrillary glomerulonephritis and immunotactoid glomerulopathy. J Am Soc Nephrol. 2008;19:34–7.
Dimopoulos MA, Panayiotidis P, Moulopoulos LA. Waldenström’s macroglobulinemia: clinical features, complications, and management. J Clin Oncol. 2000;18:214–26.
Gerz MA, Kyle RA, Noel P. Primary systemic amyloidosis: a rare complication of immunoglobulin M monoclonal gammopathies and waldenström’s macroglobulinemia. J Clin Oncol. 1993;11:914.
Veltman GA, van Veen S, Kluin-Nelemans JC. Renal disease in waldenström’s macroglobulinaemia. Nephrol Dial Transplant. 1997;12:1256.
Penfield JG. Multiple myeloma in end-stage renal disease. Semin Dial. 2006;19:329–34.
Levi M, Ellis MA, Berl T. Control of renal hemodynamics and glomerular filtration rate in chronic hypercalcemia. Role of prostaglandins, renin-angiotensin system and calcium. J Clin Invest. 1983;71(6):1624.
Dimopoulos MA, Kastritis E, Rosinol L, et al. Pathogenesis and treatment of renal failure in multiple myeloma. Leukemia. 2008;22:1485–93.
Dimopoulos M, Kyle R, Fermand JP. Guidelines for standard investigative workup: report of the international myeloma workshop consensus panel 3. Blood. Prepublished online February 2, 2011:1–17.
Rajkumar VS, Kyle AK. Multiple myeloma: diagnosis and treatment. Mayo Clin Proc. 2005;80:1371–82.
Katzmann JA, Clark RJ, Abraham RS. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem. 2002;48:1437–44.
Pratt G. The evolving use of serum free light chain assays in haematology. Br J Haematol. 2008;141:413–22.
Johnson WJ, Kyle RA, Pineda AA. Treatment of renal failure associated with multiple myeloma. Arch Intern Med. 1990;150:863–9.
Zuchelli P, Pasquali S, Cagnoli L, Ferrari G. Controlled plasma exchange trial in acute renal failure due to multiple myeloma. Kidney Int. 1998;33:1175–80.
Clark WF, Steart AK, Rock GA. Plasma exchange when myeloma presents as acute renal failure: a randomized, controlled trial. Ann Intern Med. 2005;132:777–84.
Hutchinson CA, Bradwell AR, Cook M. Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis. Clin J Am Soc Nephrol. 2009;4:745–54.
Gay F, Hayman SR, Lacy MQ, et al. Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone as initial therapy for multiple myeloma: a comparative analysis of 411 patients. Blood. 2010;115:1343.
Jagannath S, Durie BG, Wolf J, et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated multiple myeloma. Br J Haematol. 2005;129:776.
Knudsen LM, Nielsen B, Gimsing P. Autologous stem cell transplantation in multiple myeloma: outcome in patients with renal failure. Eur J Haematol. 2005;75:22–33.
Lee CK, Zangari M, Barlogie B. Dialysis-dependent renal failure in patients with myeloma can be reversed by high-dose myeloablative therapy and autotransplant. Bone Marrow Transplant. 2004;33:823–8.
Palumbo A, Bertola A, Musto P, et al. Oral melphalan, prednisone, and thalidomide for newly diagnosed patients with myeloma. Cancer. 2005;104:1428.
San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med. 2008;359:906.
Mehta J, Cavo M, Singhal M. How I treat elderly patients with myeloma. Blood. 2010;116:2215–23.
Stewart AK, Richardson PG, San-Miguel JF. How I treat multiple myeloma in younger patients. Blood. 2009;114:5436–43.
Comenzo RL. How I treat amyloidosis. Blood. 2009;114:3147–57.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media New York
About this chapter
Cite this chapter
Cormack, F.C., Richard, R.E. (2013). Multiple Myeloma and the Kidney. In: Lerma, E., Rosner, M. (eds) Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4454-1_50
Download citation
DOI: https://doi.org/10.1007/978-1-4614-4454-1_50
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-4453-4
Online ISBN: 978-1-4614-4454-1
eBook Packages: MedicineMedicine (R0)