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New Approaches to Evaluating the Pulmonary Effects of Controlled Inhalation Exposures in Human Volunteers

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Advances in Controlled Clinical Inhalation Studies

Part of the book series: ILSI Monographs ((ILSI MONOGRAPHS))

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Abstract

The respiratory tract serves as a passive portal of entry for various inhaled gases (e.g., CO) and vapors (e.g., benzene, toluene, methanol) as well as a target organ for the toxicologic effects of certain reactive gases (e.g., O3) and inhaled particulate matter. I will limit my remarks to the latter class of air pollutants and discuss only effects on the respiratory system. Nevertheless, we should bear in mind the possibility that systemic as well as localized respiratory tract effects may be attributable to inhaled toxicants. My remarks will deal with some issues in experimental protocol development, with newer experimental techniques suitable for use in human subjects, and with the promise and pitfalls of in vitro toxicologic study of human cells. Most of my illustrations will come from ozone toxicology with which I have the greatest familiarity, but which I hope will be generalizable.

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Author information

Authors and Affiliations

  1. Center for Environmental Medicine and Lung Biology, University of North Carolina, Medical Research Building C, 27599-7310, Chapel Hill, NC, USA

    P. A. Bromberg

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  1. P. A. Bromberg
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Editor information

Editors and Affiliations

  1. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Germany

    Ulrich Mohr Prof. Dr. med.

  2. Dept. Health and Epidemiology, University of British Columbia, 5804 Fairview Crescent, Mather Building, V6T 1W5, Vancouver, BC, Canada

    David V. Bates M.D., F.R.C.P., F.R.C.P.C., F.A.C.P., F.R.S.C.

  3. Abteilung Pneumologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Germany

    H. Fabel Prof. Dr. med.

  4. Pulmonary and Critical Care Unit, University of Rochester Medical Center, 601 Elmwood Avenue, 14642, Rochester, NY, USA

    Mark J. Utell M.D. (Professor of Medicine and Environmental Medicine) (Professor of Medicine and Environmental Medicine)

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© 1993 Springer-Verlag Berlin Heidelberg

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Bromberg, P.A. (1993). New Approaches to Evaluating the Pulmonary Effects of Controlled Inhalation Exposures in Human Volunteers. In: Mohr, U., Bates, D.V., Fabel, H., Utell, M.J. (eds) Advances in Controlled Clinical Inhalation Studies. ILSI Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77176-7_21

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  • DOI: https://doi.org/10.1007/978-3-642-77176-7_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77178-1

  • Online ISBN: 978-3-642-77176-7

  • eBook Packages: Springer Book Archive

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