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Convulsants Acting at the Inhibitory Glycine Receptor

  • Chapter
Selective Neurotoxicity

Part of the book series: Springer Study Edition ((SSE,volume 102))

Abstract

Inhibitory neurotransmission in the CNS is predominantly mediated by γ-aminobutyric acid (GABA) and glycine. Whereas GABAergic synapses are abundant in the cortex and cerebellum, glycine predominates in the spinal cord and brain stem (reviewed by Betz and Becker 1988; Langosch et al. 1990a,b). Glycine-mediated synaptic inhibition was first demonstrated in the spinal cord where, at the segmental level, neuronal pathways regulate the tonus of skeletal muscle (reviewed by Krnjevic 1981; Aprison 1990). Glycinergic synapses prevail in the spinal sensory, auditory, and visual system and in other parts of the CNS.

This work was supported by Deutsche Forschungsgemeinschaft (SFB 317 and Heisenberg-Programm).

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  1. Institut für Pharmakologie, Freien Universität, Thielallee 69/73, 14195, Berlin, Germany

    Hans Herken

  2. Institut für Biochemie, Freien Universität, Thielallee 63, 14195, Berlin, Germany

    Ferdinand Hucho

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Becker, CM. (1994). Convulsants Acting at the Inhibitory Glycine Receptor. In: Herken, H., Hucho, F. (eds) Selective Neurotoxicity. Springer Study Edition, vol 102. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85117-9_15

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