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New and Sensitive Method for the Spectrophotometric Determination of Certain Tricyclic Antidepressants

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Abstract.

 A new, simple, and sensitive spectrophotometric method for the determination of certain tricyclic antidepressants, belonging to the dibenzazepine class of drugs, has been developed. The proposed method is based on the reaction of imipramine hydrochloride (IPH), desipramine hydrochloride (DPH), clomipramine hydrochloride (CPH), trimipramine maleate (TPM) or opipramol (OPP) with iron(III), and subsequent reaction with ferricyanide in an acetic acid medium, to yield a blue product, with maximum absorption at 720–730 nm.

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Authors and Affiliations

  1. Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, India, , , , , , IN

    Padmarajiah Nagaraja, Mohammed Fawaz Silwadi & Akheel Ahmed Syed

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  1. Padmarajiah Nagaraja
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  2. Mohammed Fawaz Silwadi
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  3. Akheel Ahmed Syed
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Received January 24, 2000

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Nagaraja, P., Silwadi, M. & Syed, A. New and Sensitive Method for the Spectrophotometric Determination of Certain Tricyclic Antidepressants. Mikrochim Acta 135, 185–189 (2000). https://doi.org/10.1007/s006040070009

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  • DOI: https://doi.org/10.1007/s006040070009

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