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Anti-hepatitis B activity of isoquinoline alkaloids of plant origin

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Abstract

Hepatitis B virus (HBV) is the causative agent of B-type hepatitis in humans, a vaccine-preventable disease. Despite the availability of effective vaccines, globally, 2 billion people show evidence of past or current HBV infection, of which 350 million people are persistently infected, with an estimated annual increase of 1 million. There is no cure for chronic HBV infections, which are associated with cirrhotic liver failure and with an increased risk of developing hepatocellular carcinoma. Hepatitis antiviral research has focused primarily on the development of inhibitors of viral polymerase through the use of nucleoside analogues. Therefore, there is an urgent need for the development of non-nucleoside compounds to be used as an alternative or to complement the current therapy. To address this need, 18 isoquinoline alkaloids were evaluated for their potential antiviral activity against HBV in vitro.

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Abbreviations

HBV:

Hepatitis B virus

CC50 :

Concentration resulting in 50 % cytotoxicity

IC50 :

Concentration resulting in 50 % inhibition

TI:

Therapeutic index

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Acknowledgment

The authors would like to thank Dr. Michael K. Lo for critically reading the manuscript. M.A. is supported by National Health and Medical Research Council of Australia (Peter Doherty Biomedical Fellowship #APP1037092). The study is partly funded by The Deanship of Scientific Research, Qassim University, Saudi Arabia, Grant #2106.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Department of Microbiology, School of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, 3800, Australia

    Mohamad Aljofan & Hans J. Netter

  2. College of Pharmacy, Qassim University, P.O. Box 6800, Buraidah, 51452, Kingdom of Saudi Arabia

    Mohamad Aljofan & Ahmed N. Aljarbou

  3. Laboratoire de Chimie des Matériaux, Faculté des Sciences, Université Mohammed Premier, 60000, Oujda, Morocco

    Taibi Ben Hadda

  4. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330, Ankara, Turkey

    Ilkay Erdogan Orhan & Bilge Sener

  5. Pharmacognosy and Pharmaceutical Botany Unit, Faculty of Pharmacy, Eastern Mediterranean University, Gazimagosa, The Northern Cyprus

    Ilkay Erdogan Orhan

  6. BAM Communications, 111 North Bridge Road #05-32, Singapore, 179098, Singapore

    Bruce A. Mungall

Authors
  1. Mohamad Aljofan
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  2. Hans J. Netter
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  3. Ahmed N. Aljarbou
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  4. Taibi Ben Hadda
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  5. Ilkay Erdogan Orhan
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  6. Bilge Sener
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  7. Bruce A. Mungall
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Correspondence to Mohamad Aljofan.

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Aljofan, M., Netter, H.J., Aljarbou, A.N. et al. Anti-hepatitis B activity of isoquinoline alkaloids of plant origin. Arch Virol 159, 1119–1128 (2014). https://doi.org/10.1007/s00705-013-1937-7

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  • DOI: https://doi.org/10.1007/s00705-013-1937-7

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