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Anti-HIV activity of Indian medicinal plants

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Abstract

Acquired immunodeficiency syndrome patients face great socio-economic difficulties in obtaining treatment. There is an urgent need for new, safe, and cheap anti-HIV agents. Traditional medicinal plants are a valuable source of novel anti-HIV agents and may offer alternatives to expensive medicines in future. Various medicinal plants or plant-derived natural products have shown strong anti-HIV activity and are under various stages of clinical development in different parts of the world. The present study was directed towards assessment of anti-HIV activity of various extracts prepared from Indian medicinal plants. The plants were chosen on the basis of similarity of chemical constituents with reported anti-HIV compounds or on the basis of their traditional usage as immunomodulators. Different extracts were prepared by Soxhlet extraction and liquid–liquid partitioning. Ninety-two extracts were prepared from 23 plants. Anti-HIV activity was measured in a human CD4+ T-cell line, CEM-GFP cells infected with HIV-1NL4.3. Nine extracts of 8 different plants significantly reduced viral production in CEM-GFP cells infected with HIV-1NL4.3. Aegle marmelos, Argemone mexicana, Asparagus racemosus, Coleus forskohlii, and Rubia cordifolia demonstrated promising anti-HIV potential and were investigated for their active principles.

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Acknowledgment

The authors are grateful to Department of Biotechnology, Government of India for financial support to this project (Grant no. BT/PR7020/Med/14/930/2005 Date 23/05/2006).

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Authors and Affiliations

  1. National Center for Cell Sciences (NCCS), Pune University Campus, Ganeshkhind, Pune, Maharashtra, 411007, India

    Sudeep Sabde & Debashis Mitra

  2. Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, Punjab, 160062, India

    Hardik S. Bodiwala, Aniket Karmase, Preeti J. Deshpande, Amandeep Kaur, Nafees Ahmed, Siddheshwar K. Chauthe, Keyur G. Brahmbhatt, Rasika U. Phadke, Kamlesh Kumar Bhutani & Inder Pal Singh

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  1. Sudeep Sabde
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  2. Hardik S. Bodiwala
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  3. Aniket Karmase
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  4. Preeti J. Deshpande
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  5. Amandeep Kaur
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  9. Rasika U. Phadke
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  10. Debashis Mitra
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  11. Kamlesh Kumar Bhutani
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  12. Inder Pal Singh
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Corresponding authors

Correspondence to Debashis Mitra, Kamlesh Kumar Bhutani or Inder Pal Singh.

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NIPER Communication No. 479.

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Sabde, S., Bodiwala, H.S., Karmase, A. et al. Anti-HIV activity of Indian medicinal plants. J Nat Med 65, 662–669 (2011). https://doi.org/10.1007/s11418-011-0513-2

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  • DOI: https://doi.org/10.1007/s11418-011-0513-2

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