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Synthesis and Antiviral Activity of Ureides and Carbamates of Betulinic Acid and Its Derivatives

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Abstract

Ureides and carbamates of betulinic acid and its derivatives were prepared in good yields by interaction of betulinic acid, betulonic acid, and betulonic acid 3-oxime with amines, amino acids, and alcohols. Ureides of betulonic acid containingL-Val and L-Met residues were found to be effective against herpes simplex type 1 virus.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054, Russia

    O. B. Flekhter, L. R. Nigmatullina, E. V. Tret'yakova, L. A. Baltina, F. Z. Galin & G. A. Tolstikov

  2. State Research Institute of Epidemiology and Microbiology, Minsk, Belarus

    E. I. Boreko, N. I. Pavlova, S. N. Nikolaeva & O. V. Savinova

Authors
  1. O. B. Flekhter
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  2. E. I. Boreko
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  3. L. R. Nigmatullina
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  4. E. V. Tret'yakova
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  5. N. I. Pavlova
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  6. L. A. Baltina
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  7. S. N. Nikolaeva
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  8. O. V. Savinova
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  9. F. Z. Galin
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  10. G. A. Tolstikov
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Flekhter, O.B., Boreko, E.I., Nigmatullina, L.R. et al. Synthesis and Antiviral Activity of Ureides and Carbamates of Betulinic Acid and Its Derivatives. Russian Journal of Bioorganic Chemistry 29, 594–600 (2003). https://doi.org/10.1023/B:RUBI.0000008902.36604.97

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  • DOI: https://doi.org/10.1023/B:RUBI.0000008902.36604.97

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