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Comparison of gated blood pool SPECT and spiral multidetector computed tomography in the assessment of right ventricular functional parameters: validation with first-pass radionuclide angiography

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Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Objective

The aim of this study was to compare gated blood pool single photon emission computed tomography (SPECT) (GBPS) and multidetector row computed tomography (MDCT) for the determination of right ventricular ejection fraction (RVEF) and right ventricular volumes (RVV) and to compare first-pass radionuclide angiography (FP-RNA) as the gold standard.

Methods

Twenty consecutive patients (11 men, 9 women) referred for MDCT for the evaluation of the presence of coronary artery disease underwent FP-RNA and GBPS.

Results

The mean right ventricular end-diastolic volume (EDV) calculated with GBPS revealed a statistically significant lower value than that of MDCT. The mean right ventricular end-systolic volume (ESV) calculated with GBPS was also lower than that of MDCT. A comparison of right ventricular EDV from GBPS and MDCT yielded a correlation coefficient of 0.5972. Right ventricular ESV between GBPS and MDCT showed a correlation coefficient of 0.5650. The mean RVEFs calculated with FP-RNA (39.8% ± 4.0%), GBPS (43.7% ± 6.9%), and MDCT (40.4% ± 7.7%) showed no statistical differences (Kruskal–Wallis statistics 4.538, P = 0.1034). A comparison of RVEFs from FP-RNA and GBPS yielded a correlation coefficient of 0.7251; RVEFs between FP-RNA and MDCT showed a correlation coefficient of 0.6166 and between GBPS and MDCT showed a correlation coefficient of 0.6367.

Conclusion

The RVEF, EDV, and ESV calculated by GBPS had good correlation with those obtained with MDCT. In addition, there were no statistical differences of RVEF calculated from FP-RNA, GBPS, and MDCT. However, with regard to RVV, EDV and ESV from GBPS revealed statistically significantly lower values than those of MDCT. Although reasonable correlations among these modalities were obtained, the agreement among these three modalities was not good enough for interchangeable use in the clinical setting. Also, these results should be confirmed in patients with cardiac diseases in future larger population-based studies.

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References

  1. D Ropers B Baum K Pohle K Anders S Ulzheimer B Ohnesorge et al. (2003) ArticleTitleDetection of coronary artery stenoses with thin-slice multi-detector row spiral computed tomography and multiplanar reconstruction Circulation 107 664–6 Occurrence Handle12578863 Occurrence Handle10.1161/01.CIR.0000055738.31551.A9

    Article  PubMed  Google Scholar 

  2. K Nieman F Cademartiri PA Lemos R Raaijmakers PMT Pattynama PJ De Feyter (2002) ArticleTitleReliable noninvasive coronary angiography with fast sub-millimeter multislice spiral computed tomography Circulation 106 2051–4 Occurrence Handle12379572 Occurrence Handle10.1161/01.CIR.0000037222.58317.3D

    Article  PubMed  Google Scholar 

  3. KU Juergens M Grude EM Fallenberg C Opitz T Wichter W Heindel et al. (2002) ArticleTitleUsing ECG-gated multi-detector CT to evaluate global left ventricular myocardial function in patients with coronary artery disease Am J Roentgenol 179 1545–50

    Google Scholar 

  4. S Hosoi T Mochizuki M Miyagawa Y Shen K Murase J Ikezoe (2003) ArticleTitleAssessment of left ventricular volumes using multidetector row computed tomography (MDCT): phantom and human studies Radiat Med 21 62–7 Occurrence Handle12816352

    PubMed  Google Scholar 

  5. MS Dirksen JJ Bax A de Roos JW Jukema RJ van der Geest K Geleijns et al. (2002) ArticleTitleUsefulness of dynamic multislice computed tomography of left ventricular function in unstable angina pectoris and comparison with echocardiography Am J Cardiol 90 1157–60 Occurrence Handle12423725 Occurrence Handle10.1016/S0002-9149(02)02789-3

    Article  PubMed  Google Scholar 

  6. M Grude KU Juergens T Wichter M Paul EM Fallenberg JG Muller et al. (2003) ArticleTitleEvaluation of global left ventricular myocardial function with electrocardiogram-gated multidetector computed tomography. Comparison with magnetic resonance imaging Invest Radiol 38 653–61 Occurrence Handle14501493 Occurrence Handle10.1097/01.rli.0000077070.40713.76

    Article  PubMed  Google Scholar 

  7. KU Juergens M Grude D Maintz EM Fallenberg T Wichter W Heindel et al. (2004) ArticleTitleMulti-detector row CT of left ventricular function with dedicated analysis software versus MR imaging: initial experience Radiology 230 403–10 Occurrence Handle14668428 Occurrence Handle10.1148/radiol.2302030042

    Article  PubMed  Google Scholar 

  8. D Daou F Harel BO Helal T Fourme P Colin R Lebtahi et al. (2001) ArticleTitleElectrocardiographically gated blood pool SPECT and left ventricular function: comparative value of 3 methods for ejection fraction and volume estimation J Nucl Med 42 1043–9 Occurrence Handle11438625 Occurrence Handle1:STN:280:DC%2BD3MzotVyktg%3D%3D

    PubMed  CAS  Google Scholar 

  9. GA Wright S Thackray S Howey JG Cleland (2003) ArticleTitleLeft ventricular ejection fraction and volumes from gated blood pool SPECT: comparison with planar gated blood pool imaging and assessment of repeatability in patients with heart failure J Nucl Med 44 494–8 Occurrence Handle12679390

    PubMed  Google Scholar 

  10. D Daou D Vilain P Colin R Lebtahi T Fourme C Coagulia et al. (2003) ArticleTitleComparative value of ECG-gated blood pool SPET and ECG-gated myocardial perfusion SPET in the assessment of global left ventricular function Eur J Nucl Med Mol Imaging 6 859–67 Occurrence Handle10.1007/s00259-003-1121-5

    Article  Google Scholar 

  11. DS Schulman (1996) ArticleTitleAssessment of the right ventricle with radionuclide techniques J Nucl Cardiol 3 253–64 Occurrence Handle8805745 Occurrence Handle10.1016/S1071-3581(96)90039-2 Occurrence Handle1:STN:280:DyaK28zpvFWktg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  12. T Menzel T Kramm A Brückner S Mohr-Kahaly E Mayer J Meyer (2002) ArticleTitleQuantitative assessment of right ventricular volumes in severe chronic thromboembolic pulmonary hypertension using transthoracic three-dimensional echocardiography changes due to pulmonary thromboendarterectomy Eur J Echocardiogr 3 67–72 Occurrence Handle12067537 Occurrence Handle10.1053/euje.2001.0129 Occurrence Handle1:STN:280:DC%2BD38zisFSntQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  13. J Lewczuk P Piszko J Jagas A Porada S Wojciak B Sobkowicz et al. (2001) ArticleTitlePrognostic factors in medically treated patients with chronic pulmonary embolism Chest 119 818–23 Occurrence Handle11243963 Occurrence Handle10.1378/chest.119.3.818 Occurrence Handle1:STN:280:DC%2BD3M3hs1GisQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  14. S Ghio A Gavazzi C Campana C Inserra C Klersy R Sebastiani et al. (2002) ArticleTitleIndependent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure J Am Coll Cardiol 37 183–8 Occurrence Handle10.1016/S0735-1097(00)01102-5

    Article  Google Scholar 

  15. JF Polak L Holman J Wynne WS Colucci (1983) ArticleTitleRight ventricular ejection fraction: an indicator of increased mortality in patients with congestive heart failure associated with coronary artery disease J Am Coll Cardiol 2 217–24 Occurrence Handle6306086 Occurrence Handle1:STN:280:DyaL3s3jvFClsw%3D%3D Occurrence Handle10.1016/S0735-1097(83)80156-9

    Article  PubMed  CAS  Google Scholar 

  16. MS Schamberger RA Hurwitz (2000) ArticleTitleCourse of right and left ventricular function in patients with pulmonary insufficiency after repair of tetralogy of Fallot Pediatr Cardiol 21 244–8 Occurrence Handle10818184 Occurrence Handle10.1007/s002460010050 Occurrence Handle1:STN:280:DC%2BD3c3otVWjug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  17. AH Mahnken E Spuentrup M Niethammer A Buecker J Boese JE Wildberqer et al. (2003) ArticleTitleQuantitative and qualitative assessment of left ventricular volume with ECG-gated multislice spiral CT: value of different image reconstruction algorithm in comparison to MRI Acta Radiol 44 604–11 Occurrence Handle14616204 Occurrence Handle10.1080/02841850312331287799 Occurrence Handle1:STN:280:DC%2BD3srjs1ejsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  18. ML Bartlett D Seaton L McEwan W Fong (2001) ArticleTitleDetermination of right ventricular ejection fraction from reprojected gated blood pool SPET: comparison with first-pass ventriculography Eur J Nucl Med Mol Imaging 28 608–13 Occurrence Handle10.1007/s002590100503 Occurrence Handle1:STN:280:DC%2BD38%2FhtFWqtQ%3D%3D

    Article  CAS  Google Scholar 

  19. BB Chin DC Bloomgarden W Xia HJ Kim ZA Fayad VA Ferrari et al. (1997) ArticleTitleRight and left ventricular volume and ejection fraction by tomographic gated blood-pool scintigraphy J Nucl Med 38 942–8 Occurrence Handle9189147 Occurrence Handle1:STN:280:DyaK2szjt12rtw%3D%3D

    PubMed  CAS  Google Scholar 

  20. D Mariano-Goulart H Collet PO Kotzki M Zanca M Rossi (1998) ArticleTitleSemi-automatic segmentation of gated blood pool emission tomography images by watersheds: applications to the determination of right and left ejection fractions Eur J Nucl Med Mol Imaging 25 1300–7 Occurrence Handle10.1007/s002590050299 Occurrence Handle1:STN:280:DyaK1czptFOhsw%3D%3D

    Article  CAS  Google Scholar 

  21. K Nichols R Saouaf AA Ababneh RJ Barst MS Rosenbaum MW Groch et al. (2002) ArticleTitleValidation of SPECT equilibrium radionuclide angiography right ventricular parameter by cardiac magnetic resonance imaging J Nucl Cardiol 9 153–60 Occurrence Handle11986559 Occurrence Handle10.1067/mnc.2002.119464

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Pusan National University Hospital, Busan, South Korea

    Jung S. Lee

  2. Division of Cardiology, Department of Internal Medicine, Wallace Memorial Baptist Hospital, Busan, South Korea

    Jun S. Lee

  3. Department of Nuclear Medicine, Pusan National University Hospital, 1-10, Ami-dong, Seo-gu, Busan, 602-739, South Korea

    Seong-Jang Kim, In-Ju Kim & Yong-Ki Kim

  4. Medical Research Institute, Pusan National University Hospital, 1-10, Ami-dong, Seo-gu, Busan, South Korea

    Seong-Jang Kim, In-Ju Kim, Yong-Ki Kim & Ki S. Choo

  5. Department of Radiology, Pusan National University Hospital, Busan, South Korea

    Ki S. Choo

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  1. Jung S. Lee
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Correspondence to Yong-Ki Kim.

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The first two authors contributed equally to this study

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Lee, J., Lee, J., Kim, SJ. et al. Comparison of gated blood pool SPECT and spiral multidetector computed tomography in the assessment of right ventricular functional parameters: validation with first-pass radionuclide angiography. Ann Nucl Med 21, 159–166 (2007). https://doi.org/10.1007/s12149-006-0004-9

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  • DOI: https://doi.org/10.1007/s12149-006-0004-9

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