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Synthesis and molecular docking studies of chrysin derivatives as antibacterial agents

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Abstract

In order to search for drugs with excellent antibacterial activities, a series of novel chrysin derivatives were designed, synthesized, and evaluated as antibacterial agents. Results of the preliminary antibacterial tests against six human pathogenic bacteria in vitro showed that these compounds exhibited activities to some extent, and some displayed excellent activities than the natural parent chrysin, while some were even more potent than the positive drug Penicillin. Moreover, the molecular model for the binding between compound 8c and the active site of Escherichia coli β-ketoacyl-acyl carrier protein synthase III (Escherichia coli FabH) was provided on the basis of the computational docking results.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81473104). We thank Jun Zhang for the help of molecular docking.

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Authors and Affiliations

  1. School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation; Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, China

    Xinli Li, Yi Cai, Fan Yang & Qingguo Meng

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  1. Xinli Li
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  2. Yi Cai
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  3. Fan Yang
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  4. Qingguo Meng
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Correspondence to Qingguo Meng.

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Li, X., Cai, Y., Yang, F. et al. Synthesis and molecular docking studies of chrysin derivatives as antibacterial agents. Med Chem Res 26, 2225–2234 (2017). https://doi.org/10.1007/s00044-017-1952-4

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  • DOI: https://doi.org/10.1007/s00044-017-1952-4

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