A new compound, selaginellin S (1), was isolated from the whole plants of Selaginella moellendorffii Hieron. Its structure was elucidated on the basis of spectroscopic analysis and ECD calculations. Selaginellin S markedly suppressed the production of HbsAg and HBeAg with IC50 values of 0.026 and 0.032 μg/mL. The transcript of viral mRNA was significantly suppressed by selaginellin S in HepG2.2.15 cells.
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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2016, pp. 539–541.
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Zhu, B., Wang, TB., Hou, LJ. et al. A New Selaginellin from Selaginella moellendorffii Inhibits Hepatitis B Virus Gene Expression and Replication. Chem Nat Compd 52, 624–627 (2016). https://doi.org/10.1007/s10600-016-1725-1
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DOI: https://doi.org/10.1007/s10600-016-1725-1