Skip to main content

Advertisement

Log in

Granulomatous Invasive Aspergillosis of Paranasal Sinuses Masquerading as Actinomycosis and Review of Published Literature

  • Published:
Mycopathologia Aims and scope Submit manuscript

Abstract

Cutaneous aspergillosis is a common systemic mycosis affecting immunosuppressed patients. Here, we describe a novel morphological type of cutaneous aspergillosis in a young immunocompetent woman who presented with a chronic history of multiple nodules and discharging sinuses over left side of the face, mimicking cervicofacial actinomycosis. Skin biopsy showed granulomatous inflammation, and of septate fungal hyphae with acute-angled branching, morphologically resembling Aspergillus. This was confirmed on fungal culture as Aspergillus flavus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. Galimberti R, Kowalczuk A, Hidalgo Parra I, Gonzalez Ramos M, Flores V. Cutaneous aspergillosis: a report of six cases. Br J Dermatol. 1998;139:522–6.

    Article  CAS  PubMed  Google Scholar 

  2. deShazo RD, O’Brien M, Chapin K, Soto-Aguilar M, Gardner L, Swain R. A new classification and diagnostic criteria for invasive fungal sinusitis. Arch Otolaryngol Head Neck Surg. 1997;123:1181–8.

    Article  CAS  PubMed  Google Scholar 

  3. deShazo RD, Chapin K, Swain RE. Fungal sinusitis. N Engl J Med. 1997;337:254–9.

    Article  CAS  PubMed  Google Scholar 

  4. Abir B, Abouchadi A, Hamama J, Oukabli M, Nassih M, Rzin A. Invasive aspergillosis of the maxillary sinus in an immunocompetent patient. Rev Stomatol Chir Maxillofac. 2012;113:127–30.

    Article  CAS  PubMed  Google Scholar 

  5. Alrajhi AA, Enani M, Mahasin Z, Al-Omran K. Chronic invasive aspergillosis of the paranasal sinuses in immunocompetent hosts from Saudi Arabia. Am J Trop Med Hyg. 2001;65:83–6.

    CAS  PubMed  Google Scholar 

  6. Milosev B, el-Mahgoub S, Aal OA, el-Hassan AM. Primary aspergilloma of paranasal sinuses in the Sudan. A review of seventeen cases. Br J Surg. 1969;56:132–7.

    Article  CAS  PubMed  Google Scholar 

  7. Gupta AK. Postgraduate institute management protocol for invasive Aspergillus flavus sinusitis : is it effective? Int J Infect Dis. 2009;13:134–9.

    Article  PubMed  Google Scholar 

  8. Miloshev B, Davidson CM, Gentles JC, Sandison AT. Aspergilloma of paranasal sinuses and orbit in Northern Sudanese. Lancet. 1966;1:746–7.

    Article  CAS  PubMed  Google Scholar 

  9. Green WR, Font RL, Zimmerman LE. Asperillosis of the orbit. Report of ten cases and review of the literature. Arch Ophthalmol. 1969;82:302–13.

    Article  CAS  PubMed  Google Scholar 

  10. Veress B, Malik OA, el-Tayeb AA, el-Daoud S, Mahgoub ES, el-Hassan AM. Further observations on the primary paranasal aspergillus granuloma in the Sudan: a morphological study of 46 cases. Am J Trop Med Hyg. 1973;22:765–72.

    CAS  PubMed  Google Scholar 

  11. Talwar P, Sharma M, Sehgal SC, Ghose KK. Serology of Aspergillus granuloma. Mycopathologia. 1982;79:79–85.

    Article  CAS  PubMed  Google Scholar 

  12. Challa S, Uppin SG, Hanumanthu S, Panigrahi MK, Purohit AK, Sattaluri S, et al. Fungal rhinosinusitis: a clinicopathological study from South India. Eur Arch Otorhinolaryngol. 2010;267:1239–45.

    Article  PubMed  Google Scholar 

  13. Pushker N, Meel R, Kashyap S, Bajaj MS, Sen S. Invasive aspergillosis of orbit in immunocompetent patients: treatment and outcome. Ophthalmology. 2011;118:1886–91.

    Article  PubMed  Google Scholar 

  14. Findlay GH, Roux H, Simson I. Skin manifestations in disseminated aspergillosis. Br J Dermatol. 1971;85(Suppl):94–7.

    Article  Google Scholar 

  15. Won HR, Park JH, Kim KS. Simultaneous actinomycosis with aspergillosis in maxillary sinus. Br J Oral Maxillofac Surg. 2013;51:e51–3.

    Article  PubMed  Google Scholar 

  16. Khatri ML, Stefanato CM, Benghazeil M, Shafi M, Kubba A, Bhawan J. Cutaneous and paranasal aspergillosis in an immunocompetent patient. Int J Dermatol. 2000;39:853–6.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amrinder J. Kanwar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vinay, K., Khullar, G., Yadav, S. et al. Granulomatous Invasive Aspergillosis of Paranasal Sinuses Masquerading as Actinomycosis and Review of Published Literature. Mycopathologia 177, 179–185 (2014). https://doi.org/10.1007/s11046-014-9732-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11046-014-9732-x

Keywords

Navigation