Summary
In 64 patients with psoriasis and in 54 persons without any skin disease the amount of zinc was estimated in plasma and in the erythrocytes using atomic absorption spectrophotometry. The findings showed an elevated plasma level and a lower zinc content of blood erythrocytes in psoriasis. Both values were statistically significant. No relation was found between these changes and the percentage skin surface covered by psoriatic lesions. The disturbed distribution of zinc in psoriasis may be due to disturbances of histidine metabolism or to changes of the permeability of the cell membranes associated with this skin disease.
Zusammenfassung
An 64 Psoriatiker fand sich eine statistisch signifikante Erhöhung des Zinkspiegels im Plasma und eine ebenfalls statistisch signifikante Minderung des Zinkgehalts in den Bluterythrocyten, verglichen mit 54 gesunden Personen. Die erhobenen Befunde zeigten keine Relation zur Ausdehnung der Hautkrankheit. Die Verteilungsstörung dieses Spurenelements bei Psoriasis könnte auf eine Störung des Histidin-Stoffwechsels oder auf Veränderungen der Erythrocytenmembran beruhen.
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Herrn Prof. Dr. J. Capetanakis, Direktor der Universitäts-Hautklinik Athen, zum Geburtstag gewidmet
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Tsambaos, D., Orfanos, C.E. Zinkverteilungsstörung bei psoriasis. Arch. Derm. Res. 259, 97–100 (1977). https://doi.org/10.1007/BF00562742
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DOI: https://doi.org/10.1007/BF00562742