Abstract
In a double-blind cross-over study using normal student volunteers, the effects of 1 and 2.5 mg lorazepam on self-rated mood and bodily symptoms, as well as performance in a number of tests were assessed. Both doses significantly increased self ratings of physical and mental sedation, the effects being more marked 4 h after drug administration than after 1 h. Lorazepam impaired simple reaction time, verbal learning, number cancellation, symbol copying and performance in the digit-symbol substitution test. The impairments were greater with the 2.5 mg dose and were more marked 4 h after drug administration than after 1 h.
References
Bond, A. J., Lader, M. H.: The use of analogue scales in rating subjective feeling. Br. J. Med. Psychol. 47, 211–208 (1974)
Bond, A. J., Lader, M. H.: The psychotropic profile of tofisopam. Psychopharmacology, in press (1980)
Brown, J., Lewis, V., Brown, M. W., Horn, G., Bowes, J. B.: Amnesic effects of intravenous diazepam and lorazepam. Experientia 34, 501–502 (1978)
Clarke, P. R. F., Eccersley, P. F., Frisbt, J. P., Thornton, J. A.: The amnesic effect of diazepam (valium). Br. J. Anaesth. 42, 690–697 (1970)
Collard, J.: Initial psychopharmacological study of lorazepam (Wy 4036). Arzneim. Forsch. 21, 1091–1095 (1971)
Elliot, H. W., Nomob, N., Navarro, G., Ruelius, H. W., Knowles, J. A., Corner, W. H.: Clin. Pharmacol. Ther. 12, 468–481 (1971)
George, K. A., Dundee, J. W.: Relative amnesic actions of diazepam, flunitrazepam and lorazepam in man. Br. J. Clin. Pharmacol. 4, 45–50 (1977)
Harry, T. V. A., Richards, D. J.: Lorazepam. A study in psychomotor depression. Brit. J. Clin. Pract. 26, 371–373 (1972)
Hedges, A., Turner, P., Harry, T. V.: Preliminary studies on the central nervous effects of lorazepam, a new benzodiazepine. J. Clin. Pharmacol. 16, 423–427 (1971)
Knowles, J. A., Comer, W. H., Ruelius, H. W.: Disposition of 7-7-7-7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in humans. Arzneim. Forsch. 21, 1055–1058 (1971)
Pandit, S. K., Heisterkamp, D. V., Cohen, P. J.: Further studies of the anti-recall effect of lorazepam: A dose-time-effect relationship. Anesthesiology 45, 495–500 (1976)
Randall, L. O., Kappell, B.: Pharmacological activity of some benzodiazepines and their metabolites. In: The benzodiazepines, S. Garattini, E. Mussini, L. O. Randall, eds., pp. 27–51. New York: Raven 1973
Skegg, D. C. G., Doll, R., Perry, J.: Use of medicines in general practice. Br. Med. J. 1, 1561–1563 (1977)
Wyeth Technical Booklet: Ativan injection and tablets. Taplow, Berks.: John Wyeth & Brother Ltd. 1978
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File, S.E., Bond, A.J. Impaired performance and sedation after a single dose of lorazepam. Psychopharmacology 66, 309–313 (1979). https://doi.org/10.1007/BF00428325
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DOI: https://doi.org/10.1007/BF00428325