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Hyperthermic modulation of macrophage-tumor cell interactions

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Abstract

Hyperthermia in the febrile (≤41° C) or tumor therapeutic (≥42° C) ranges is known to alter tumor-host interactions: there are reports of either inhibitory or enhancing effects on tumor metastasis and various host defense mechanisms. Historically, this has been an area of conflicting and often anecdotal reports, and there are still significant gaps in our knowledge of the effects of temperature on tumor-host interactions. However, we believe that the tools are now available to further our understanding of the complex relationships between febrile episodes or therapeutically applied heat and various tumor-host cytotoxic mechanisms, and that potentially important and exploitable relationships can be defined. In this review we give an overview of the current status of this field and the factors that have shaped it. We also describe our recent experimental work with macrophages and their monokines, primarily tumor necrosis factor (TNF), which we feel offers new scientific and clinical opportunities for future studies.

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References

  1. Dickson JA: The effects of hyperthermia in animal tumour systems. In: Rossi-Fanelli R, Cavaliere R, Mondovi B, Morica G (eds) Selective Heat Sensitivity of Cancer Cells. Springer-Verlag, New York, 1977, pp 43–111

    Google Scholar 

  2. Wallach DFH. Basic mechanisms in tumor thermotherapy. Journal of Molecular Medicine 2: 381–403, 1977

    Google Scholar 

  3. Dickson JA, Shah SA: Hyperthermia: the immune response and tumor metastasis. NCI Monogr 61: 183–192, 1982

    Google Scholar 

  4. Hill SA, Denckamp J: Does local tumor heating in mice influence metastatic spread? Br J Radiol 55: 444–451, 1982

    Google Scholar 

  5. Muckle DS, Dickson JA: The selective inhibitory effect of hyperthermia on the metabolism and growth of malignant cells. Br J Cancer 25: 771–778, 1971

    Google Scholar 

  6. Dickson JA, Muckle DS: Total-body hyperthermia in the treatment of the rabbit VX-2 carcinoma. Cancer Res 32: 1916–1923, 1972

    Google Scholar 

  7. Mondovi B, Santoro AS, Strom R, Faiola R, Fanelli AR: Increased immunogenicity of Ehrlich ascites cells after heat treatment. Cancer 30: 885–888, 1972

    Google Scholar 

  8. Dickson JA, Ellis HA: Stimulation of tumor cell dissemination by raised temperature (42° C) in rats with transplanted Yoshida tumours. Nature 248: 354–358, 1974

    Google Scholar 

  9. Yerushalmi A: Influence on metastatic spread of whole-body or local tumor hyperthermia. Eur J Cancer 12: 455–463, 1976

    Google Scholar 

  10. Roszkowski W, Wrembel JK, Roszkowski K, Janiak M, Szmigielski S: Does whole-body hyperthermia therapy involve participation of the immune system? Int J Cancer 25: 289–292, 1980

    Google Scholar 

  11. Mihich E: Biological response modifiers: their potential and limitations in cancer therapeutics. Cancer Invest 3: 71–83, 1985

    Google Scholar 

  12. Roberts NJJr: Temperature and host defense. Microbiol Rev 43: 241–259, 1979

    Google Scholar 

  13. Azocar J, Yunis EJ, Essex M: Sensitivity of human natural killer cells to hyperthermia. Lancet 1: 16–17, 1982

    Google Scholar 

  14. Kalland T, Dahlquist I: Effects of in vitro hyperthermia on human natural killer cells. Cancer Res 43: 1842–1846, 1983

    Google Scholar 

  15. Dinarello CA, Dempsey RA, Allegretta M, LoPreste G, Dainiale N, Parkinson DR, Mier JW: Inhibitory effects of elevated temperatures on human cytokine production and natural killer activity. Cancer Res 46: 6236–6241, 1986

    Google Scholar 

  16. Downing JF, Taylor MW: The effect of in vivo hyperthermia on selected lymphokines in man. Lymphokine Res 6: 103–109, 1987

    Google Scholar 

  17. Shen R-N, Hornback NB, Shidnia H, Shupe RE, Brahmi Z: Whole-body hyperthermia decreases lung metastases in lung tumor-bearing mice possibly via a mechanism involving natural killer cells. J Clin Immunol 7: 246–253, 1987

    Google Scholar 

  18. Fidler IJ: Macrophages and metastasis—a biological approach to cancer therapy. Cancer Res 45: 4714–4726, 1985

    Google Scholar 

  19. Shah SA: Metastasis and hyperthermia. In: Anghileri LJ, Robert J (eds) Hyperthermia in Cancer Treatment, Vol. I. CRC Press, Boca Raton, 1986, pp 191–227

    Google Scholar 

  20. Overgaard K, Overgaard J: Investigations on the possibility of a thermic tumor therapy. I. Short-wave treatment of a transplanted isologous mouse mammary carcinoma. Eur J Cancer 8: 65–78, 1972

    Google Scholar 

  21. Manzella JP, Roberts NJJr: Human macrophage and lymphocyte response to mitogen stimulation after exposure to influenza virus, ascorbic acid, and hyperthermia. J Immunol 123: 1940–1944, 1979

    Google Scholar 

  22. Roberts NJJr, Sandberg K: Hyperthermia and human leukocyte functions. II. Enhanced production of and response to leukocyte migration inhibition factor (LIF). J Immunol 122: 1990–1993, 1979

    Google Scholar 

  23. Roberts NJJr, Lu S-T, Michaelson SM: Hyperthermia and human leukocyte functions: DNA, RNA and total protein synthesis after exposure to <41° C or >42.5° C hyperthermia. Cancer Res 45: 3076–3082, 1985

    Google Scholar 

  24. Andreesen R, Osterholz J, Schulz A, Lohr GW: Enhancement of spontaneous and lymphokine activated human macrophage cytotoxicity by hyperthermia. Blut 47: 225–229, 1983

    Google Scholar 

  25. Landry JM, Lord EM, Sutherland RM: In vivo growth of tumor cell spheroids after in vitro hyperthermia. Cancer Res 42: 93–99, 1982

    Google Scholar 

  26. Wilson KM, Lord EM: Specific (EMT6) and non-specific (WEHI-164) cytolytic activity by host cells infiltrating tumor spheroids. Br J Cancer 55: 141–146, 1987

    Google Scholar 

  27. Szmigielski S, Janiak M, Hrniewicz W, Jeljaszewicz J, Pulverer G: Local microwave hyperthermia (43° C) and stimulation of the macrophage and T-lymphocyte systems in treatment of Guerin epithelioma in rats. Zeitschrift für Krebsforschung 91: 35–48, 1978

    Google Scholar 

  28. Szmigielski S, Janiak M: Reaction of cell-mediated immunity to local hyperthermia and its potentiation by immunostimulation—a review. In: Streffer C, van Beuningen D, Dietze F, Rottinger E, Robinson JE, Scherer E, Seeber S, Trott K-R (eds) Cancer Therapy by Hyperthermia and Radiation. Urban and Schwarzenberg, Baltimore, 1978, pp 80–88

    Google Scholar 

  29. Shah SA: Participation of the immune system in regression of a rat MC7 sarcoma by hyperthermia. Cancer Res 41: 1742–1747, 1981

    Google Scholar 

  30. Urano M, Suit HD, Dunn P, Lansdale T, Sedlacek S: Enhancement of the thermal response of animal tumors by Corynebacterium paruum. Cancer Res 39: 3454–3457, 1979

    Google Scholar 

  31. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 72: 3666–3670, 1975

    Google Scholar 

  32. Matthews N, Watkins JF: Tumor-necrosis factor from the rabbit. I. Mode of action, specificity and physicochemical properties. Br J Cancer 38: 302–309, 1978

    Google Scholar 

  33. Adams DO, Johnson WJ, Marino PA: Mechanisms of target recognition and destruction in macrophage-mediated tumor cytotoxicity. Fed Proc 41: 2212–2221, 1982

    Google Scholar 

  34. Old LJ: Tumor necrosis factor (TNF). Science 230: 630–632, 1985

    Google Scholar 

  35. Urban JL, Shepard HM, Rothstein JL, Sugarman BJ, Schreiber H: Tumor necrosis factor: a potent effector molecular for tumor cell killing by activated macrophages. Proc Natl Acad Sci USA 83: 5233–5237, 1986

    Google Scholar 

  36. Decker J, Lohmann-Mathes M-L, Gifford GE: Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages. J Immunol 138: 957–962, 1987

    Google Scholar 

  37. Klostergaard J, Lotzova E: Monocyte Symposium: Introductory remarks. Natural Immunity and Cell Growth Regulation 7: 249–253, 1988

    Google Scholar 

  38. Klostergaard J, Barta M, Tomasovic SP: Hyperthermic modulation of tumor necrosis factor-dependent monocyte/macrophage tumor cytotoxicity in vitro. J Biol Response Mod 8: 262–277, 1989

    Google Scholar 

  39. Tomasovic SP, Barta M, Klostergaard J: Temporal dependence of hyperthermic augmentation of macrophage-TNF production and tumor cell-TNF sensitization. Int J Hyperthermia 5: 625–639, 1989

    Google Scholar 

  40. Kriegler M, Perez C, DeFay K, Albert I, Lu SD: A novel form of TNF/cachectin is a cell surface cytotoxic membrane protein: ramifications for the complex physiology of TNF. Cell 53: 45–53, 1988

    Google Scholar 

  41. Klostergaard J, Foster WA, Leroux ME: Tumoricidal effector mechanisms of murine BCG-activated macrophages. I. Parameters of production and initial characterization of a factor serologically related to necrosin. J Biol Response Mod 6: 313–330, 1987

    Google Scholar 

  42. Yershalmi A, Tovey MG, Gresser I: Antitumor effect of combined interferon and hyperthermia in mice. Proc Soc Exp Biol Med 169: 413–415, 1982

    Google Scholar 

  43. Groveman DS, Borden EC, Meritt JA, Robins HI, Steeves R, Bryan GT: Augmented antiproliferative effects of interferons at elevated temperatures against human bladder carcinoma cell lines. Cancer Res 44: 5517–5521, 1984

    Google Scholar 

  44. Fleischmann WR, Fleischmann CM, Gindhart TD: Effect of hyperthermia on the antiproliferative activities of murine α-, β-, and γ-interferons: differential enhancement of murine γ-interferon. Cancer Res 46: 8–13, 1986

    Google Scholar 

  45. Roberts NJJr. Differential effects of hyperthermia on human leukocyte production of interferon-α and interferon-γ. Proc Soc Exp Biol Med 183: 42–47, 1986

    Google Scholar 

  46. Downing JF, Taylor MW, Wei K-M, Elizondo RS: In vivo hyperthermia enhances plasma antiviral activity and stimulates peripheral lymphocytes for increased synthesis of interferon-γ. J Interferon Res 7: 185–193, 1987

    Google Scholar 

  47. Neville AJ, Sauder DN: Whole body hyperthermia (41–42° C) induces interleukin-1 in vivo. Lymphokine Res 7: 201–206, 1988

    Google Scholar 

  48. Schmidt JA, Abdulla E: Down-regulation of IL-1β biosynthesis by inducers of the heat-shock response. J Immunol 141: 2027–2034, 1988

    Google Scholar 

  49. Philip R, Epstein LB: Tumor necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1. Nature 323: 86–89, 1986

    Google Scholar 

  50. Nathan CF: Secretory products of macrophages. J Clin Invest 79: 319–326, 1987

    Google Scholar 

  51. Klostergaard J, Leroux ME, Ezell SM, Kull FCJr: Tumoricidal effector mechanisms of murine Bacillus Calmette-Guerin-activated macrophages: mediation of cytolysis, mitochondrial respiration inhibition, and release of intracellular iron by distinct mechanisms. Cancer Res 47: 2014–2019, 1987

    Google Scholar 

  52. Luettig B, Decker T, Lohmann-Matthes M-L: 26kD molecule as a lytic mechanism of mouse macrophage membranes. Abstract #69-51. 7th International Congress of Immunology, Berlin, July 30–August 5, 1989 p 426

  53. Scuderi P: Suppression of human leukocyte tumor necrosis factor sceretion by the serine protease inhibitor p-toluenesulfonyl-L-arginine methyl ester (TAME). J Immunol 143: 168–173, 1989

    Google Scholar 

  54. Hahn GM: Hyperthermia and Cancer. Plenum Press, New York, 1982

    Google Scholar 

  55. Anghileri LJ: Role of tumor cell membrane in hyperthermia. In: Anghileri LJ, Robert J (eds) Hyperthermia in Cancer Treatment, Vol. I. CRC Press, Boca Raton, 1986, pp 1–36

    Google Scholar 

  56. Elkon D, McGrath HE: Thermal inactivation energy of granulocyte-monocyte stem cells. Radiat Res 87: 368–372, 1981

    Google Scholar 

  57. Bromer RH, Mitchell JB, Soares N: Response of human hematopoietic precursor cells (CFUc) to hyperthermia and radiation. Cancer Res 42: 1261–1265, 1982

    Google Scholar 

  58. Agarwal SS, Katz EJ, Loeb LA: Effect of hyperthermia on the survival of normal human peripheral blood mononuclear cells. Cancer Res 43: 3124–3126, 1983

    Google Scholar 

  59. Werts ED, Smith KM: Temporal response of murine bone marrow to local hyperthermia. Int J Radiat Oncol Biol Phys 10: 2315–2321, 1984

    Google Scholar 

  60. Van Zant G: Effects of hyperthermia on hematopoietic tissues. In: Anghileri L, Robert J (eds) Hyperthermia in Cancer Treatment, Vol. II. CRC Press, Boca Raton, 1986, pp 59–73

    Google Scholar 

  61. Mivechi NF, Li GC: Lack of development of thermotolerance in early progenitors of murine bone marrow cells. Cancer Res 46: 198–202, 1986

    Google Scholar 

  62. Carper SW, Duffy JJ, Gerner EW: Heat shock proteins in thermotolerance and other cellular processes. Cancer Res 47: 5249–5255, 1987

    Google Scholar 

  63. Tomasovic SP: Functional aspects of the mammalian cellular heat-stress-protein response. In: Bannister JV, Michelson AM (eds) Life Chemistry Reports, Vol. 7. Harwood Academic Publishers, New York, 1989, pp 33–63

    Google Scholar 

  64. Klostergaard J, Barta M, Tomasovic SP: Hyperthermia and endotoxin coregulate activated macrophage expression of heat-stress proteins. Paper presented to Society for Leukocyte Biology (RES Society). Marco Island, FL, October 12–15, 1989. J Leukocyte Biol., in press

  65. Haranaka K, Sakurai A, Satoni N: Antitumor activity of recombinant human tumor necrosis factor in combination with hyperthermia, chemotherapy or immunotherapy. J Biol Response Mod 6: 379–391, 1987

    Google Scholar 

  66. Sato N, Goto T, Haranaka K, Satomi N, Nariuchi H, Mano-Hirano Y, Sawasaki Y: Action of tumor necrosis factor on cultured vascular endothelial cells: morphologic modulation, growth inhibition, and cytotoxicity. J Natl Cancer Inst 76: 1113–1121, 1986

    Google Scholar 

  67. Kawai T, Satomi N, Sato, Sakurai A, Haranaka K, Goto T, Suzuki M: Effects of tumor necrosis factor (TNF) on transplanted tumor induced by methylcholanthrene in mice: a histopathologic study. Virchows Arch [B] 52: 489–500, 1987

    Google Scholar 

  68. Watanabe N, Niitsu Y, Umeno H, Kuriyama H, Neda H, Yamauchi N, Maeda M, Urushizaki T: Toxic effect of tumor necrosis factor on tumor vasculature in mice. Cancer Res 48: 2179–2183, 1988

    Google Scholar 

  69. Niitsu Y, Watanabe N, Umeno H, Sone H, Neda H, Yamauchi N, Maeda M, Urushizak I: Synergistic effects of recombinant human tumor necrosis factor and hyperthermia on in vitro cytotoxicity and artificial metastasis. Cancer Res 48: 654–657, 1988

    Google Scholar 

  70. Watanabe N, Niitsu Y, Umeno H, Sone H, Neda H, Yamauchi N, Maeda M, Urushizak I: Synergistic cytotoxic and antitumor effects of recombinant human tumor necrosis factor and hyperthermia. Cancer Res 48: 650–653, 1988

    Google Scholar 

  71. Maeda T, Fuchimoto S, Orita K: Hyperthermic enhancement of the antitumor effect of natural human tumor necrosis factor-α and-β: an in vitro and in vivo study. Jpn J Cancer Res 79: 1054–1061, 1988

    Google Scholar 

  72. Ruff MR, Gifford GE: Rabbit tumor necrosis factor: mechanism of action. Infect Immunol 31: 380–385, 1981

    Google Scholar 

  73. Wong GHW, Goeddel DV: Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science 242: 941–943, 1988

    Google Scholar 

  74. Dealtry GB, Naylor MS, Fiers W, Balkwill FR: DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon-γ. Eur J Immunol 17: 689–693, 1987

    Google Scholar 

  75. Schmid DS, Hornung R, McGrath KM, Paul N, Ruddle NH: Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor. Lymphokine Res 6: 195–202, 1987

    Google Scholar 

  76. Klostergaard J, Barta M, Tomasovic SP: Hyperthermic modulation of respiratory inhibition factor-and iron-releasing factor-dependent macrophage cytotoxicity. Cancer Res 49: in press, 1989

  77. Tomasovic SP, Barta M, Klostergaard J: Neutral red uptake and clonogenic survival assays of the hyperthermic sensitization of tumor cells to tumor necrosis factor. Radiat Res 119: 325–337, 1989

    Google Scholar 

  78. Agah R, Malloy B, Sherrod A, Mazumder A: Successful therapy of natural killer-resistant pulmonary metastases by the synergism of γ-interferon with tumor necrosis factor and interleukin-2 in mice. Cancer Res 48: 2245–2248, 1988

    Google Scholar 

  79. Borden EC, Sidky YA, Hatcher JR, Bryan GT: Schedule-dependent variation in the response of murine P388 leukemia to cyclophosphamide in combination with interferons-α/β. Cancer Res 48: 2329–2334, 1988

    Google Scholar 

  80. Souchek JM, Leroux ME, Klostergaard J: Sensitization of tumor target cells to cytolysis by murine macrophage cytolytic factor by drugs inhibiting DNA, RNA, and protein synthesis. J Leukocyte Biol 40: 755–768, 1986

    Google Scholar 

  81. Haranaka K, Satomi N, Sakurai A: Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice. Int J Cancer 34: 263–267, 1984

    Google Scholar 

  82. Watanabe N, Niitsu Y, Neda H, Sone H, Yamauchi N, Umetsu T, Urushizaki I: Antitumor effect of tumor necrosis factor against various primarily cultured human cancer cells. Jpn J Cancer Res 76: 1115–1119, 1985

    Google Scholar 

  83. Creasey AA, Reynolds MT, Laird W: Cures and partial regression of murine and human tumors by recombinant human tumor necrosis factor. Cancer Res 46: 5687–5690, 1986

    Google Scholar 

  84. Heicappell R, Naito S, Ichinose Y, Creasey AA, Lin LS, Fidler IJ: Cytostatic and cytolytic effects of human recombinant tumor necrosis factor on human renal cell carcinoma cell lines derived from a single surgical specimen. J Immunol 138: 1634–1640, 1987

    Google Scholar 

  85. Manda T, Shimomura K, Mukumoto S, Kobayashi K, Mizota T, Hirai O, Matsumoto S, Oku T, Nishigaki F, Mori J, Kikuchi H: Recombinant human tumor necrosis factor-α: Evidence of an indirect mode of antitumor activity. Cancer Res 47: 3707–3711, 1987

    Google Scholar 

  86. Klebanoff SJ, Vadas MA, Harlan JM, Sparks LH, Gamble JR, Agosti JM, Waltersdorph AM: Stimulation of neutrophils by tumor necrosis factor. J Immunol 136: 4220–4225, 1986

    Google Scholar 

  87. Hori K, Ehrke MJ, Mace K, Maccubbin D, Doyle MJ, Otsuka Y, Mihich E: Effect of recombinant human tumor necrosis factor on the induction of murine macrophage tumoricidal activity. Cancer Res 47: 2793–2798, 1987

    Google Scholar 

  88. Kawai T, Satomi N, Sato N, Sakurai A, Haranaka K, Goto T, Suzuki M: Necrotizing activity of tumor necrosis factor: Histopathological investigation using Meth A sarcoma and granulation tissue. Virchows Arch [B] 53: 353–358, 1987

    Google Scholar 

  89. Leibovich SJ, Polverin PJ, Shepard HM, Wiseman DM, Shively V, Nuseir N: Macrophage-induced angiogenesis is mediated by tumor necrosis factor-α. Nature 329: 630–632, 1987

    Google Scholar 

  90. Mano-Hirano Y, Sato N, Sawasaki Y, Haranaka K, Satomi N, Nariuchi H, Goto T: Inhibition of tumor-induced migration of bovine capillary endothelial cells by mouse and rabbit tumor necrosis factor. J Natl Cancer Inst 78: 115–120, 1987

    Google Scholar 

  91. Ming WJ, Bersani L, Mantovani A: Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes. J Immunol 138: 1469–1474, 1987

    Google Scholar 

  92. Old LJ: Polypeptide mediator network. Nature 326: 330–331, 1987

    Google Scholar 

  93. Spriggs D, Imamura K, Rodriguez C, Horiguchi J, Kufe DW: Induction of tumor necrosis factor expression and resistance in a human breast tumor cell line. Proc Natl Acad Sci USA 84: 6563–6566, 1987

    Google Scholar 

  94. Li GC, Laszlo A: Thermotolerance in mammalian cells: a possible role for heat shock proteins. In: Atkinson BG, Walden DB (eds) Changes in Eukaryotic Gene Expression in Response to Environmental Stress. Academic Press, New York, 1984, pp 227–254

    Google Scholar 

  95. Fidler IJ, Sone S, Fogler WE, Barnes ZL: Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyl dipeptide. Proc Natl Acad Sci USA 78: 1680–1684, 1981

    Google Scholar 

  96. Lopez-Berestein G, Milas L, Hunter N, Mehta K, Hersh EM, Kurahara CG, VanderPas MA, Eppstein DA: Prophylaxis and treatment of experimental lung metastases in mice after treatment with liposome-encapsulated 6-O-stearoyl-N-acetylmuramyl-L-α-aminobutyryl-D-isoglutamine. Clin Exp Metastasis 2: 127–137, 1984

    Google Scholar 

  97. Saiki I, Milas L, Hunter N, Fidler IJ: Treatment of experimental lung metastasis with local thoracic irradiation followed by systemic macrophage activation with liposomes containing muramyltripeptide. Cancer Res 46: 4966–4970, 1986

    Google Scholar 

  98. Kilbourn RG, Klostergaard J, Lopez-Berestein G: Activated macrophages secrete a soluble factor that inhibits mitochondrial respiration of tumor cells. J Immunol 133: 2577–2581, 1984

    Google Scholar 

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  1. Department of Tumor Biology, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA

    Stephen P. Tomasovic & Jim Klostergaard

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  1. Stephen P. Tomasovic
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Tomasovic, S.P., Klostergaard, J. Hyperthermic modulation of macrophage-tumor cell interactions. Cancer Metast Rev 8, 215–229 (1989). https://doi.org/10.1007/BF00047338

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