Skip to main content
SpringerLink
Log in

Pattern reversal retinal potentials in ocular hypertensives at high and low risk of developing glaucoma

  • Published:
Documenta Ophthalmologica Aims and scope Submit manuscript

Abstract

The human pattern-reversal retinal potential (PRRP) is a bioelectrical response which reflects neural activity generated in the proximal retina. Visual diseases which affect the retinal ganglion cells and the optic nerve often produce significant reductions in the amplitude of the PRRP. PRRP amplitude reductions are frequently observed in patients with primary open-angle glaucoma. This investigation was designed to determine whether patients with ocular hypertension who are at risk of developing glaucoma also exhibit PRRP amplitude reductions. The results indicate that PRRP amplitude reductions do occur in some ocular hyptertensives, but many other ocular hypertensives do not exhibit PRRP abnormalities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Adams AJ, Rodic R, Husted R and Stamper R (1982) Spectral sensitivity and color discrimination changes in glaucoma and glaucoma suspect patients. Invest Ophthalmol and Vis Sci 23/516

    Google Scholar 

  • Atkin A, Wolstein M, Bodis-Wollner I, Anders M, Kels B and Podos SM (1980) Interocular comparison of contrast sensitivities in glaucoma patients and suspects. Brit J Ophthalmol 64: 858

    Google Scholar 

  • Bobak P, Bodis-Wollner I, Harnois C, Maffei L, Mylin L, Podos S and Thornton J (1983) Pattern electroretinograms and visual evoked potentials in glaucoma and multiple sclerosis. Amer J Ophthalmol 96: 72

    Google Scholar 

  • Dawson WW, Maida T and Rubin ML (1982) Human pattern evoked retinal responses are altered by optic nerve atrophy. Invest Ophthalmol and Vis Sci 22: 796

    Google Scholar 

  • Dawson WW, Trick GL and Litzkow C (1979) An improved electrode for electroretinography. Invest Ophthalmol and Vis Sci 18: 988

    Google Scholar 

  • Hart WM Jr, Yablonski M, Kass M and Becker B (1979) Multivariate analysis of the risk of glaucomatous visual field loss. Arch Ophthalmol 97: 1455

    Google Scholar 

  • Hollander H, Bisti S, Maffei L and Hebel R (1984) Electroretinographic responses and retrograde changes of retinal morphology after intracranial optic nerve section. A quantitative analysis in the cat. Exp Brain Res 55: 483

    Google Scholar 

  • Maffei L and Fiorentini A (1981) Electroretinographic responses to alternating gratings before and after section of the optic nerve. Science 211: 953

    Google Scholar 

  • May JG, Ralston JV, Reed JL and Vaan Dyck HJL (1982) Loss in pattern elicited electroretinograms in optic nerve dysfunction. Amer J Ophthalmol 93: 418

    Google Scholar 

  • Quigley HA, Hohman RM, Addicks EM, Massof RW and Green WR (1983) Morphologic changes in the lamina cribrosa correlated with neural losss in open-angle glaucoma. Am J Ophthalmol 95: 673

    Google Scholar 

  • Quigley HA and Hendrickson A (1984) Chronic experimental glaucoma in primates: Blood flow study with iodoantipyrine and pattern of selective ganglion cell loss. Invest Ophthalmol and Vis Sci (ARVO Supple) 25: 225

    Google Scholar 

  • Regan D and Neima D (1984) Balance between pattern and flicker sensitivities in the visual fields of ophthalomological patients. Brit J Ophthalmol 68/310

    Google Scholar 

  • Seiple W, Price MJ, Kupersmith M and Carr RE (1983) The pattern electroretinogram in optic nerve disease. Ophthalmology 90: 1127

    Google Scholar 

  • Towle VL, Moskowitz A, Sokol S and Schwanz B (1983) The visual evoked potential in glaucoma and ocular hypertension: Effects of check size, field size and stimulation rate. Invest Ophthalmol and Vis Sci 24: 175

    Google Scholar 

  • Trick GL. Retinal potentials in patients with primary openangle glaucoma: Physiological evidence for temporal tuning deficits. Invest Ophthalmol and Vis Sci (in press)

  • Tyler CW (1981) Specific deficits in flicker sensitivity in glaucoma and ocular hypertension. Invest Ophthalmol and Vis Sci 20: 204

    Google Scholar 

  • van Lith G, Ringens P and de Heer LJ (1984) Pattern electroretinogram and glaucoma. Developments in Ophthalmolgy (Vol ]), Straub W ed. S Karger, Basel

    Google Scholar 

  • Wanger P and Persson HE (1983) Pattern-reversal electro-retinograms in unilateral glaucoma. Invest Ophthalmol and Vis Sci 24: 749

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Washington University School of Medicine, 63110, St. Louis, MO, USA

    Gary L. Trick

Authors
  1. Gary L. Trick
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by Research Grant EY 04464 from the National Eye Institute.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Trick, G.L. Pattern reversal retinal potentials in ocular hypertensives at high and low risk of developing glaucoma. Doc Ophthalmol 65, 79–85 (1987). https://doi.org/10.1007/BF00162723

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00162723

Key words

Search

Navigation