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A NlaIII polymorphism within the human factor VII gene

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Abstract

The polymorphism is located within exon 5 of the human coagulation factor VII gene and is silent at the amino acid level. The distribution pattern is similar in Caucasians and African Americans. This polymorphism may be useful for restriction fragment length polymorphism (RFLP) diagnosis of factor X deficiency as well as factor VII deficiency, since the factor X gene is closely linked to the factor VII locus.

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Authors and Affiliations

  1. Department of Hospital Laboratories, The University of North Carolina Hospitals, 27514, Chapel Hill, NC, USA

    Shu Huey Chaing

  2. Division of Hematology, Children's Hospital of Philadelphia, 34th Street and Civic Center Blvd., 19104, Philadelphia, PA, USA

    Katherine A. High

  3. Department of Medicine, Coagulation Disorders, Malmö General Hospital, Malmö, Sweden

    Anders Wallmark & Erik Berntorp

Authors
  1. Shu Huey Chaing
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  2. Anders Wallmark
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  3. Erik Berntorp
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  4. Katherine A. High
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Chaing, S.H., Wallmark, A., Berntorp, E. et al. A NlaIII polymorphism within the human factor VII gene. Hum Genet 93, 722–723 (1994). https://doi.org/10.1007/BF00201584

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  • DOI: https://doi.org/10.1007/BF00201584

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