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The effect of timing of a single injection on the toxicity of methotrexate in the rat

  • Original Articles
  • Timing and Methotrexate Toxicity
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Summary

The possibility of a circadian rhythm in the toxicity of methotrexate was investigated in rats after a single intravenous bolus. Indices of haematological, renal and hepatic toxicity were studied, as were the pharmacokinetics of the drug. All the parameters showed a circadian variation, with maximum toxicity occurring after dosage at 06.00 h and minimum toxicity after dosage at midnight. Administration at the other two time points, 12.00 h and 18.00 h, gave intermediate results.

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Authors and Affiliations

  1. Division of Clinical Biochemistry, Department of Biochemistry, University of Surrey, Guildford, Surrey, Great Britain

    Judie English, G. Wynne Aherne & Vincent Marks

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  1. Judie English
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  2. G. Wynne Aherne
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  3. Vincent Marks
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English, J., Wynne Aherne, G. & Marks, V. The effect of timing of a single injection on the toxicity of methotrexate in the rat. Cancer Chemother. Pharmacol. 9, 114–117 (1982). https://doi.org/10.1007/BF00265390

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  • DOI: https://doi.org/10.1007/BF00265390

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