Summary
We have examined the presentation of low back pain in three patients with ochronosis, and have reviewed the literature. Low back pain and/or stiffness is the first presenting feature and usually appears after the age of 30. Discolouration of the ear is almost always present. Characteristic radiographic changes in the lumbar spine include calcification of the intervertebral discs and lucencies in the discs. The process gradually extends to the entire spine.
Résumé
Les auteurs étudient la lombalgie de l'ochronose à partir de trois cas personnels et de la revue de la littérature. Les douleurs lombaires et la raideur sont les premiers symptômes de cette maladie, ils apparaissent habituellement après l'âge de trente ans. La décoloration de l'oreille est quasi constante. Les modifications radiologiques du rachis lombaire associent la calcification des disques intervertébraux à des zones claires au niveau de ces disques. Progressivement, la maladie atteint la totalité de la colonne vertébrale.
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References
Christensen K, Manthorpe R (1983) Alkaptonuria and ochronosis. A survey and 5 cases. Hum Hered 33: 140–144
Detenbeck LC, Young HH, Underdahl LO (1970) Ochronotic arthropathy. Arch Surg 100: 215–219
Kampik A, Sani JN, Green WR (1980) Ocular ochronosis. Clinicopathological histochemical and ultrastructural studies. Arch Ophthalmol 98: 1441–1447
Lagier R, Sit' Aj S (1974) Vertebral changes in ochronosis. Anatomical and radiological study of one case. Ann Rheum Dis 33: 86–92
McClure J, Smith PS, Gramp AA (1983) Calcium pyrophosphate dihydrate (CPPD) deposition in ochronotic arthropathy. J Clin Pathol 36: 894–902
McKusick VA (1979) Heritable and developmental disorders of connective tissues and bone. In: McCarty DJ (ed) Arthritis and allied conditions. 9th ed, Lea and Febiger, Philadelphia, pp 971–975
O'Brien WM, La Du BN, Bunim JJ (1963) Biochemical, pathologic and clinical aspects of alkaptonuria, ochronosis and ochronotic arthropathy. Review of world literature (1584–1962). Am J Med 34: 813–838
Schumacher HR, Holdsworth DE (1977) Ochronotic arthropathy. 1. Clinicopathologic studies. Semin Arthritis Rheum 6: 207–246
Schumacher HR (1979) Ochronosis, hemochromatosis and Wilsons disease. In: McCarty DJ (ed) Arthritis and allied conditions. Lea and Febiger, Philadelphia, 9th ed, pp 1262–1268
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Sakkas, L., Thouas, B., Smyrnis, P. et al. Low back pain and ochronosis. International Orthopaedics 11, 19–21 (1987). https://doi.org/10.1007/BF00266053
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DOI: https://doi.org/10.1007/BF00266053