Summary
The histogenesis of colloid cyst of the third ventricle remains unsettled. Ultrastructural and immunohistochemical analyses have suggested the following possible origins: (a) neuroepithelium, including paraphysis, ependyma, choroid plexus and tela chorioidea; and (b) endoderm, including respiratory and enteric epithelium. This report describes the ultrastructural features of the lining epithelium in four cases of colloid cyst. Six distinct cell types were recognized: (1) ciliated cells with occasional abnormal cilia; (2) non-ciliated cells with microvilli coated with granulofibrillary material; (3) goblet cells showing discharge of secretory granules; (4) basal cells with prominent tonofilaments and desmosomes; (5) basal-located cells with elongated electron-lucent cytoplasm and scattered membrane-bound dense-core granules (150–350 nm); and (6) small undifferentiated cells with scanty organelles. Junctional complexes were present in the former four cell types but absent in the latter two. The types of epithelial cells and their topographic distribution within the epithelium are both very similar to those of normal respiratory epithelium and to the lining epithelium of intraspinal bronchogenic cyst. The observations made in the present study are compatible with the hypothesis that colloid cysts of the third ventricle originate from the endoderm, most likely the respiratory epithelium.
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References
Bonikos DS, Bensch KG (1977) Endocrine cells of bronchial and bronchiolar epithelium. Am J Med 63:765–771
Breeze RG, Wheeldon EB (1977) The cells of pulmonary airways. Am Rev Respir Dis 116:705–777
Campbell E, Schwind JL (1939) Goblet cells in colloid cyst of the third ventricle. Yale J Biol Med 11:501–506
Coxe WS, Luse SA (1964) Colloid cyst of third ventricle. An electron microscopic study. J Neuropathol Exp Neurol 23:431–445
Dempsey LC, Nielsen SL (1976) Surface ultrastructure of human ependyma. J Neurosurg 45:52–55
Ghatak NR, Kassoff I, Alexander E Jr (1977) Further observation on the fine structure of a colloid cyst of the third ventricle. Acta Neuropathol (Berl) 39:101–107
Haymaker W, Yenermen MH (1955) Pathological features of colloid cysts of the third ventricle. A consideration of 80 cases. Excerp Med (Amst), Sect VIII
Hirano A (1981) A guide to neuropathology. Igaku-Shoin, New York, pp 298–306
Hirano A, Ghatak NR (1974) The fine structure of colloid cysts of the third ventricle. J Neuropathol Exp Neurol 33:333–341
Ho KL, Chason JL (1987) A glioependymal cyst of the cerebellopontine angle. Immunohistochemical and ultrastructural studies. Acta Neuropathol 74:382–388
Ho KL, Tiel R (1989) Intraspinal bronchogenic cyst: ultrastructural study of the lining epithelium. Acta Neuropathol 78:513–520
Jeffrey PK (1983) Morphological features of airway surface epithelial cells and glands. Am Rev Respir Dis 128:514–520
Jeffrey PK, Reid L (1975) New observations of rat airway epithelium: a quantitative and electron microscopic study. J Anat 120:295–320
Kappers JA (1955) The development of the paraphysis cerebri in man with comments on its relationship to the intercolumnar tubercle and its significance for the origin of cystic tumours in the third ventricle. J Comp Neurol 102:425–509
Kepes JJ (1970) Colloid cysts of the third ventricle. Are they really of paraphyseal or ependymal origin? Acta Neurol Scand 46:628–629
Kondiziolka D, Bilbao JM (1989) An immunohistochemical study of neuroepithelial (colloid) cysts. J Neurosurg 71:91–97
Lach B, Scheithauer BW (1986) Histogenesis of the colloid cyst of the 3rd ventricle. Immunohistochemical study. Abstracts of the 10th International Congress of Neuropathology, Stockholm, Sept 2–8, 1986, Gotab, Stockholm, p 77
Landolt-Weber UM (1973) Ultrastruktur einer Kolloidcyste des dritten Ventrikels. Acta Neuropathol (Berl) 26:59–70
Leech RW, Olafson RA (1977) Epithelial cysts of the neuraxis. Presentation of three cases and a review of the origins and classification. Arch Pathol Lab Med 101:196–202
Leech RW, Freeman T, Johnson R (1982) Colloid cyst of the third ventricle. A scanning and transmission electron microscopic study. J Neurosurg 57:108–113
MacKenzie JRA, Gilbert JJ (1991) Cysts of the neuraxis of endodermal origin. J Neurol Neurosurg Psychiatry 54:572–575
McDowell EM, Barrett LA, Trump BF (1976) Observations on small granule cells in adult human bronchial epithelium and in carcinoids and oat cell tumors. Lab Invest 34:202–206
McKeever PE, Brissie NT (1977) Scanning electron microscopy of neoplasms removed at surgery: surface topography and comparison of meningioma, colloid cyst, ependymoma, pituitary adenoma, schwannoma and astrocytoma. J Neuropathol Exp Neurol 36:875–896
Miettinen M, Clark R, Virtanen I (1986) Intermediate filament proteins in choroid plexus and ependyma and their tumors. Am J Pathol 123:231–240
Nitta M, Symon L (1985) Colloid cysts of the third ventricle. A review of 36 cases. Acta Neurochir (Wien) 76:99–104
Peters A, Palay SL, Webster HdeF (1976) The fine structure of the nervous system. The neurons and supporting cells. Saunders, Philadelphia, pp 238–239, 338–339
Ramsey H (1965) Fine structure of the surface of the cerebral cortex of human brain. J Cell Biol 26:323–333
Russell DS, Rubinstein LJ (1989) Pathology of tumours of the nervous system, 5th edn. Williams and Wilkins, Baltimore, pp 721–725
Shibata T, Burger PC, Kleihues P (1986) Origin of colloid cyst: immunohistochemical study using anti-cytokeratins and S-100 protein. Abstracts of the 10th International Congress of Neuropathology, Stockholm, Sept 7–12, 1986. Gotab, Stockholm, p 77
Shuangshoti S, Netsky MG (1966) Neuroepithelial (colloid) cysts of the nervous system. Further observations on pathogenesis, location, incidence, and histochemistry. Neurology 16:887–903
Shuangshoti S, Roberts MP, Netsky MG (1965) Neuroepithelial (colloid) cysts. Pathogenesis and relation to choroid plexus cyst and ependyma. Arch Pathol 80:214–224
Shuangshoti S, Phisitbutr M, Kasantikul V, Netsky MG (1977) Multiple neuroepithelial (colloid) cysts: association with other congenital anomalies. Neurology 27:561–566
Stochdorph VO (1963) Zur Abkunft der Foramen-Monroi-Cysten. Nervenarzt 34:226–229
Uematsu Y, Komai N, Hirano A, Llena JF, Rojas-Corona RR (1990) Comparison of cytokeratins expression in colloid cyst of third ventricle and Rathke's cleft cyst in the sella. Abstracts of the 11th International Congress of Neuropathology, Kyoto, Sept 2–8, 1990, p 261
Yagishita S, Itoh Y, Shozawa T, Tanaka T (1984) Ultrastructural observation on a colloid cyst of the third ventricle. A contribution to its pathogenesis. Acta Neuropathol (Berl) 65:41–45
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Presented in part at the Annual Meeting of the American Association of Neuropathologists, Baltimore, MD, June 20–23, 1991
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Ho, K.L., Garcia, J.H. Colloid cysts of the third ventricle: ultrastructural features are compatible with endodermal derivation. Acta Neuropathol 83, 605–612 (1992). https://doi.org/10.1007/BF00299409
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DOI: https://doi.org/10.1007/BF00299409