Summary
The antimyotonic effect of the antiarrhythmic drug tocainide was tested in 14 patients. With 1200 to 1600 mg/d all patients reported good improvement. This was substantiated by objective tests. Only four patients noticed minor side effects.
Zusammenfassung
Die antimyotone Wirkung des Antiarrhythmikums Tocainid wurde an 14 myotonen Patienten untersucht. Bei Tagesdosen von 1200–1600 mg berichteten alle Patienten über gute Unterdrückung der Myotonie; dies wurde durch objektive Tests bestätigt. Nur 4 Patienten berichteten geringfügige Nebeneffekte.
References
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Rüdel, R., Dengler, R., Ricker, K. et al. Improved therapy of myotonia with the lidocaine derivative tocainide. J Neurol 222, 275–278 (1980). https://doi.org/10.1007/BF00313157
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DOI: https://doi.org/10.1007/BF00313157