Skip to main content
SpringerLink
Log in

Isolated central nervous system granulomatosis resembling sarcoidosis

  • Short Communications
  • Published:
Journal of Neurology Aims and scope Submit manuscript

Summary

Isolated central nervous system (CNS) granulomatosis resembling sarcoidosis occurred in a 30-year-old woman who had amenorrhea, ataxia, and obstructive hydrocephalus, and a 9-year course of progressive neurological deterioration with recurrent bouts of diabetes insipidus. Lamellar and nodular meningeal hyalinosis resembling amyloid was noted on an initial brain biopsy. At autopsy, the brain had a non-necrotizing granulomatous meningitis and ventriculitis, most prominent at the base of the brain, including the third ventricle and the hypothalamus, but there were no systemic granulomas.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Delaney P (1977) Neurologic manifestations of sarcoidosis: review of the literature with a report of 23 cases. Ann Intern Med 87:336–345

    Google Scholar 

  2. Douglas AC, Maloney FJ (1973) Sarcoidosis of central nervous system. J Neurol Neurosurg Psychiatry 36:1024–1033

    Google Scholar 

  3. Engleman P, Lerbow AA, Gemlich J, Fridman PJ (1987) Pulmonary hyalinizing granuloma. Am Rev Respir Dis 115:997–1008

    Google Scholar 

  4. James DG, Sharma OP (1967) Neurosarcoidosis. Proc R Soc Med 60:1169–1170

    Google Scholar 

  5. James DG, Williams WJ (1985) Sarcoidosis and other granulomatous disorders. In: Smith LH (ed) Major problems in internal medicine. Saunders, Philadelphia; pp 89–96

    Google Scholar 

  6. Manz HJ (1983) Pathobiology of neurosarcoidosis and clinicopathologic correlation. Can J Neurol Sci 10:50–55

    Google Scholar 

  7. Oksanen V (1986) Neurosarcoidosis: clinical presentations and course in 50 patients. Acta Neurol Scand 73:283–290

    Google Scholar 

  8. Stern BJ, Krumholz A, Johns CJ (1986) Neurosarcoidosis: presentation and management. Ann NY Acad Sci 465:722–730

    Google Scholar 

  9. Ulrich H (1977) Neurosarcoidosis or granulomatous angiitis: a problem of definition. Mt Sinai J Med 44:718–725

    Google Scholar 

  10. Waxman JS, Sher JH (1979) The spectrum of central nervous system sarcoidosis. A clinical and pathologic study. Mt Sinai J Med 36:309–317

    Google Scholar 

  11. Wiederholt WC, Siekert RC (1965) Neurologic manifestations of sarcoidosis. Neurology 15:1147–1154

    Google Scholar 

  12. Yousen SA, Hochholzer L (1987) Pulmonary hyalinizing granuloma. Am J Clin Pathol 87:1–6

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology (Neuropathology) and the Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, NY, USA

    S. C. Lee & D. W. Dickson

  2. Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA

    J. Rumberg

  3. Department of Pathology, Mount Vernon Medical Center, Mount Vernon, NY, USA

    J. Spencer

Authors
  1. S. C. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Spencer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Rumberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. W. Dickson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, S.C., Spencer, J., Rumberg, J. et al. Isolated central nervous system granulomatosis resembling sarcoidosis. J Neurol 236, 356–358 (1989). https://doi.org/10.1007/BF00314381

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00314381

Key words

Search

Navigation