Abstract
The principles governing neural pattern generation were studied in the pyloric subsystem of lobster stomatogastric ganglion. Quantitative estimates were obtained for repetitive-firing and synaptic-interaction parameters for use in developing quantitative theories (including computer models) of ganglion functioning. 1. The neurons fired tonically to depolarizing current steps, adapting to about 30% of initial frequency along a compound exponential with time-constants around 0.3 and 3.5 s. 2. Both initial and final firing frequencies to depolarizing current steps were approximately logarithmic with current over a substantial current range (2–10 nA). 3. Post-hyperpolarization rebound was exhibited by all cell types. Its magnitude was a linear function of current in some but not all cases. In simple cases build-up followed a compound exponential with time constants similar to those for adaptation. 4. Synaptic potentials were of two general types: sharprising (t peak≃12 ms) and rounded (t peak≃80 ms). 5. Effective synaptic strengths were measured between neuron types. In some cases the strengths were sufficient to expect complete shut-off of moderate activity in postsynaptic elements by moderate activity in presynaptic elements. 6. Certain properties of the system enhance switch-like on/off activity in each cell, which could contribute to burst generation and to appropriate phasing of bursts in the activity cycle.
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Hartline, D.K., Gassie, D.V. Pattern generation in the lobster (Panulirus) stomatogastric ganglion. Biol. Cybernetics 33, 209–222 (1979). https://doi.org/10.1007/BF00337410
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DOI: https://doi.org/10.1007/BF00337410