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Morphology of early changes in liver carcinogenesis induced by methapyrilene

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Abstract

Two weeks of treatment with the liver carcinogen methapyrilene induced a significant increase in mitochondria of periportal hepatocytes in F344 rats. Administration of [3H]-methapyrilene hydrochloride resulted in a pronounced concentration of bound radioactivity in the periportal hepatocytes, with mitochondria being the principal site of intracellular binding. The nuclei of the liver cells were unlabeled.

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Authors and Affiliations

  1. Chemical Carcinogenesis Program, Frederick Cancer Research Center, 21701, Frederick, MD, USA

    Hildegard M. Reznik-Schüller & William Lijinsky

Authors
  1. Hildegard M. Reznik-Schüller
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  2. William Lijinsky
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Additional information

This work was supported by Contract No. N01-CO-75380 with the National Cancer Institute, NIH, Bethesda, MD 20205.

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Reznik-Schüller, H.M., Lijinsky, W. Morphology of early changes in liver carcinogenesis induced by methapyrilene. Arch Toxicol 49, 79–83 (1981). https://doi.org/10.1007/BF00352075

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  • DOI: https://doi.org/10.1007/BF00352075

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