Conclusion
Insulin resistance and Type 2 diabetes are accompanied by a progressive deterioration of the microcirculation in many tissues. The mechanism behind this association is obscure but currently accepted data may be arranged to fit a pathogenic model with vascular and circulatory changes causing a decline of muscle blood flow that finally leads to the metabolic disorder.
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Ganrot, P.O. Insulin resistance syndrome: possible key role of blood flow in resting muscle. Diabetologia 36, 876–879 (1993). https://doi.org/10.1007/BF00400365
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DOI: https://doi.org/10.1007/BF00400365