Summary
The effect of 120-h sleep deprivation on the activity of selected enzymes of energy metabolism in skeletal muscle was studied in seven healthy volunteers. The results showed a significant decrease in the activity of malate dehydrogenase, citrate synthase, glycerol-3-phosphate dehydrogenase and lactate dehydrogenase. Triosephosphate dehydrogenase, hexokinase, and hydroxyacyl-CoA-dehydrogenase activities showed an insignificant decrease. The findings are indicative of (1) decreased aerobic oxidation capacity; (2) reduced function of reducing-equivalent carriers from cytosol across the mitochondrial membrane; (3) relative accentuation of the non-aerobic glycolytic pathway; (4) a prediabetic type of muscle metabolism.
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Vondra, K., Brodan, V., Bass, A. et al. Effects of sleep deprivation on the activity of selected metabolic enzymes in skeletal muscle. Europ. J. Appl. Physiol. 47, 41–46 (1981). https://doi.org/10.1007/BF00422481
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DOI: https://doi.org/10.1007/BF00422481