Summary
This study was undertaken to investigate the dose-response relationship between the biological effect and noise exposure, and to consider the mechanism of the appearance of noise effects. Rats were exposed to noise at intensities of 60 dB (A), 80 dB (A) and 100 dB (A) for 240 min and examined for the change of activities of dopamine-Β-hydroxylase (DBH) in serum and adrenal glands. Plasma cyclic adenosine 3′,5′-monophosphate (c-AMP) levels were also measured. Some rats were given 6-hydroxydopamine (6-OHDA) as a chemical sympathectomyzing agent 20 h before noise exposure in order to consider the mechanism of the appearance of noise effects. By noise exposure, serum DBH activity was significantly (P<0.01) increased at each intensity compared with the control group, but there were no remarkable changes in adrenal DBH activity. Plasma c-AMP level was also significantly elevated in response to the noise stress. When the rats, which had been pretreated with 6-OHDA, were exposed to noise with an intensity of 100 dB (A), the response of serum DBH activity was no longer observed. Therefore it is suggested that the effect due to noise exposure appears through the post-ganglionic sympathetic nerve fiber.
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References
Friedman S, Kaufman S (1965) 3,4-dihydroxyphenylethylamine Β-hydroxylase. J Biol Chem 240: 4763–4773
Gewirtz GP, Kopin IJ (1970) Release of dopamine-Β-hydroxylase with norepinephrine during cat splenic nerve stimulation. Nature 227: 406–407
Goldstein M, Freedman LS, Bonnay M (1971) An assay for dopamine-Β-hydroxylase activity in tissues and serum. Experientia 27: 632–633
Honma M, Satoh T, Takezawa J, Ui M (1977) An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue. Biochem Med 18: 257–273
Jansen G, Roy PY (1962) Der Einflüsse der Bandbreite eines GerÄusches auf die starke vegetative Reaktionen. Int Z Angew Physiol Arbeitsphysiol 19: 587–599
Kirschner N (1957) Pathway of noradrenaline formation from DOPA. J Biol Chem 226: 821–825
Lehmann G (1961) Die Einwirkung des LÄrms auf den Menschen. Westdeutscher Verlag, Opladen
Nagatsu I (1974) Axonal flow. Adv Neurol Sci 18: 308–321
Oura Z (1961) Experimental studies on some effect of noise to living body. Jpn J Public Health 8: 227–238
Steiner AL, Pagliara AS, Chase LR, Kipnis DM (1972) Radioimmunoassay for cyclic nucleotides. II. Adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in mammalian tissues and body fluid. J Biol Chem 247: 1114–1120
Tanaka T, Furukawa T, Ouchi T, Tanaka S (1976) Pharmacological study on serum dopamine-Β-hydroxylase. Clin Physiol [Tokyo] 6: 266–270
Tranzer JP, Thoenen H (1967) Ultramorphologische VerÄnderungen der sympatischen Nervenendigungen der Katze nach Vorbehandlung mit 5- und 6-Hydroxy-Dopamin. Naunyn-Schmiedebergs Arch Pharmakol 257: 343–344
Weinshilboum R, Axelrod J (1971) Serum dopamine-beta-hydroxylase activity. Circ Res 28: 307–315
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Okada, A., Ariizumi, M. & Okamoto, G. Study on the mechanism of the appearance of noise effects. Europ. J. Appl. Physiol. 53, 364–367 (1985). https://doi.org/10.1007/BF00422855
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DOI: https://doi.org/10.1007/BF00422855