Abstract
Streptomyces flaveolus, strain Tü 1240 produces besides Tirandamycin A, a hitherto unknown antibiotic, which is closely related to Tirandamycin A. The new antibiotic Tirandamycin B contains one additional hydroxylgroup. Both antibiotics exhibit a similar antimicrobial spectrum and they seem to have the same mechanism of action. According to the data obtained from mass spectrometry, 13C-and 1H-NMR spectra formula II could be deduced for Tirandamycin B.
Zusammenfassung
Ein Stamm von Streptomyces flaveolus, Tü 1240, bildet neben dem schon länger bekannten Tirandamycin A das Tirandamycin B, das sich durch eine zusätzliche Hydroxylgruppe von A unterscheidet. Beide Antibiotica besitzen ein ähnliches Wirkungsspektrum und offensichtlich gleichen Wirkunsmechanismus. Anhand der Daten aus der Massenspektrometric, der 13C-und 1H-NMR-Spektren läßt sich dem Tirandamycin B die Formel II zuordnen.
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157. Mitteilung: H. Diddens, H. Zähner, E. Kraas, W. Göhring, G. Jung: On the transport of two tripeptide antibiotics in bacteria. Europ. J. Biochem. (in press)
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Hagenmaier, H., Jaschke, K.H., Santo, L. et al. Stoffwechselprodukte von Mikroorganismen. Arch. Microbiol. 109, 65–74 (1976). https://doi.org/10.1007/BF00425114
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DOI: https://doi.org/10.1007/BF00425114