Abstract
Rats were pretreated with methylscopolamine. One group received neostigmine or physostigmine followed by methylphenidate. Physostigmine, but not neostigmine prevented the occurrence of stereotyped gnawing behavior. Another group received methylphenidate followed by physostigmine or neostigmine. Physostigmine abolished rat stereotyped gnawing behavior.
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This research was supported in part by grant GM 15431, from the National Institutes of Health, grant MH 11468, from the National Institute of Mental Health, and by research support from The State of Tennessee Dept. of Mental Health.
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Janowksy, D.S., El-Yousef, M.K., Davis, J.M. et al. Cholinergic antagonism of methylphenidate-induced stereotyped behavior. Psychopharmacologia 27, 295–303 (1972). https://doi.org/10.1007/BF00429382
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DOI: https://doi.org/10.1007/BF00429382