Abstract
Alcohol (1–3 g/kg) significantly increased the concentration of cerebrospinal fluid (CSF) norepinephrine (NE) in rhesus monkeys. This effect is consistent with the previously demonstrated activational and possible antidepressant effect of low doses of alcohol. The greatest increase was observed in subjects with low baseline levels of CSF NE. Individual differences in activation or euphoria could be related to differential increases in CSF NE following alcohol consumption.
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Ahlenius S, Engel J, Svensson TH, Sodersten P (1973) Antagonism by alpha methyltyrosine of the ethanol-induced stimulation and euphoria in man. Clin Pharmacol Ther 14:586–551
Amit Z, Brown ZW, Levitan DE, Orgen SO (1977) Noradrenergic mediation of the positive reinforcing properties of ethanol. I. Suppression of ethanol consumption in laboratory rats following dopamine-beta-hydroxylase inhibition. Arch Int Pharmacodyn Ther 230:65–75
Amit Z, Brown ZW (1982) Actions of drugs of abuse on brain reward systems: A reconsideration with specific attention to alcohol. Pharmacol Biochem Behav 17:233–238
Brown ZW, Amit Z (1977) The effects of selective catecholamine depletions by 6-hydroxydopamine on ethanol preference in rats. Neurosci Lett 5:333–336
Carlsson A, Engel J, Svensson TH (1972) Inhibition of ethanol-induced excitation in mice and rats by alpha-methyl-p-tyrosine. Psychopharmacology 26:307–312
Carlsson A, Magnusson T, Svensson TH, Waldeck B (1973) Effect of ethanol on the metabolism of brain catecholamines. Psychopharmacology 30:27–36
Chernow B, Lake CR, Cruess D, Coyle J, Hughes P, Balesstrieri F, Casey L, Rainey TG, Fletcher JR (1982) Plasma, urine, and CSF catecholamine concentrations during and after ketamine anesthesia. Crit Care Med 10:600–603
Corrodi HK, Fuxe K, Hokfelt T (1966) The effect of ethanol on the activity of central catecholamine responses in rat brain. J Pharm Pharmacol 18:821–832
Davis WM, Smith SG, Werner TE (1978) Noradrenergic role in self-administration of alcohol. Pharmacol Biochem Behav 9:369–374
Davis WM, Werner TE, Smith SG (1979) Reinforcement with intragastric infusions of ethanol: Blocking effect of FLA-57. Pharmacol Biochem Behav 11:545–548
Degani NC, Sellers EM, Kadzielawa K (1979) Ethanol-induced spontaneous norepinephrine release from the rat vas deferens. J Pharmacol Exp Ther 210:22–26
Ebert MH, Katzinel R, Cowdry RW, Goodwin FK (1979) Cerebrospinal fluid amine metabolites and the probenecid test. In: Wood JH (ed) Neurobiology of cerebrospinal fluid. Plenum New York, pp 97–112
Engel J, Strombom U, Svensson TH, Waldeck B (1974) Suppression by alpha-methyl-tyrosine of ethanol-induced locomotor stimulation: Partial reversal by L-dopa. Psychopharmacology 37:275–279
Fisher RA (1951) The design of experiments. (6th ed) Oliver and Boyd, Edinburgh, London
Israel Y, Carmichael FJ, Macdonald JA (1973) Effect of ethanol on norepinephrine uptake and electrically stimulated release in brain tissue. Ann NY Acad Sci 215:38–48
Kiianmaa K, Fuxe K, Jonsson G, Ahtee L (1975) Evidence of involvement of central NA neurones in alcohol intake. Increased alcohol consumption after degeneration of the N pathway to the cerebri. Neurosci Lett 1:41–45
Kraemer GW, McKinney WT (1979) Interactions of pharmacological agents which alter biogenic amine metabolism and depression: An analysis of contributing factors within a primate model of depression. J Affective Disord 1:33–54
Kraemer GW, Lin DH, Kalin N, Ebert MH, McKinney WT (1979) Effect of ethyl alcohol and d-amphetamine on social behavior and the response to peer separation in rhesus monkeys. Neurosci Abs 5:652
Kraemer GW, Lin DH, Moran EC, McKinney WT (1981) Effects of alcohol on the despair response to peer separation in rhesus monkeys. Psychopharmacology 73:307–310
Kraemer GW, Ebert MH, McKinney WT (1983) Separation models and depression, In: Angst J (ed) The origins of depression: Current concepts and approaches. Springer, Berlin, pp 133–146
Lake CR, Ziegler MG, Kopin IJ (1976) Use of plasma NE for evaluation of sympathetic neurone function in man. Life Sci 18:1313–1326
Lerner P, Major LF, Ziegler M, Dendel PS, Ebert MH (1980) Central noradrenergic adaptation to long-term treatment with imipramine in rhesus monkeys. Brain Res 200:220–224
Majchrowicz E (1973) Alcohol, aldehydes, and biogenic amines. Ann NY Acad Sci 215:84–88
Matchett JA, Erickson CK (1977) Alteration of ethanol-induced changes in locomotor activity by adreneric blockers in mice. Psychopharmacology 52:201–206
Murphy JM, McBride WJ, Lumeng L, Li TK (1982) Regional brain levels of monoamines in alcohol-preferring and non-preferring lines of rats. Pharmacol Biochem Behav 16:145–149
Murphy JM, McBride WJ, Lumeng L, Li TK (1983) Monoamine and metabolite levels in CNS regions of the P line of alcohol preferring rats after acute and chronic alcohol treatment. Pharmacol Biochem Behav 19:849–856
Perlow M, Chiueh CC, Lake CR, Wyatt RJ (1980) Increased dopamine and norepinephrine concentrations in primate CSF following amphetamine and phenylethylamine administration. Brain Res 186:469–473
Pohorecky LA (1974) Effects of ethanol on central and peripheral noradrenergic neurons. J Pharmacol Exp Ther 189:380–391
Pohorecky LA, Brick J (1977) Activity of neurons in the locus coeruleus of the rat. Inhibition by ethanol. Brain Res 131:174–179
Rech RH, Borys HK, Moore KE (1966) Alterations in behavior and brain catecholamine levels in rats treated with alpha methyltyrosine. J Pharmacol Exp Ther 153:412–419
Strombom U, Svensson TH, Carlsson A (1977) Antagonism of ethanol's central stimulation in mice by small doses of catecholamine-receptor agonists. Psychopharmacology 51:293–299
Suomi SJ, Seaman SF, Lewis JK, DeLizio RD, McKinney WT (1978) Effects of imipramine treatment of separation-induced social disorders in rhesus monkeys. Arch Gen Psychiatry 35:321–325
Ziegler MG, Lake CR, Wood JH, Ebert MH (1976) Circadian rhythm in cerebrospinal fluid noradrenaline of man and monkey. Nature 264:656–658
Ziegler MG, Lake CR, Ebert MH (1979a) Norepinephrine elevations in cerebrospinal fluid after d- and l-amphetamine. Eur J Pharmacol 57:127–133
Ziegler MG, Lake CR, Wood JH, Ebert MH (1979b) Norepinephrine in cerebrospinal fluid: Basic studies, effects of drugs and disease. In: Wood JH (ed) Neurobiology of cerebrospinal fluid. Plenum, New York, pp 141–152
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Kraemer, G.W., Raymond Lake, C., Ebert, M.H. et al. Effects of alcohol on cerebrospinal fluid norepinephrine in rhesus monkeys. Psychopharmacology 85, 444–448 (1985). https://doi.org/10.1007/BF00429662
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DOI: https://doi.org/10.1007/BF00429662