Summary
A rare case of primary malignant mixed mesodermal tumor of the gallbladder arising in a 75 year old woman is reported. The previously published cases of similar tumors were reviewed in order to outline the histological features and the histogenesis. In diagnosing a malignant mixed mesodermal tumor of the gallbladder it was imperative that we excluded malignant neoplasms with multiple histological patterns. The diffuse and close intermingling of the epithelial and mesenchymal component ruled out a collision tumor. The high mitotic rate, the typical reticulin pattern and the obviously malignant osteoblasts excluded a spindle cell carcinoma with osseous metaplasia. The authors conclude that this is the first case of malignant mixed mesodermal tumor with evident osteosarcomatous areas, described in the gallbladder.
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References
Appelman HD, Coopersmith N (1970) Pleomorphic spindle cell carcinoma of the gallbladder. Cancer 25:535–541
Appelman HD, Oberman HA (1965) Squamous cell carcinoma of the larynx with sarcoma like stroma. A clinicopathologic assessment of spindle carcinoma and “pseudosarcoma”. Am J Clin Pathol 44:135–145
Christopherson WM, Richardson M (1981) Uterine mesenchymal tumors. In: Sommers SC (ed) Pathology annual Appleton-Century-Crofts. New York pp. 215–246
Das Gupta TK, Hajdu SI, Foote FW Jr (1968) Extraosseous osteogenic sarcoma. Ann Surg 168:1011–1022
Edmonson HA (1962) Tumors of the gallbladder and extrahepatic bile ducts. Atlas of tumor pathology. Armed Forces Institute of Pathology, Washington D.C.
Ellis PSJ, Whitehead R (1981) Mitosis counting. A need for reappraisal. Hum Pathol 12:3–4
Hendrickson MR, Kempson RL (1980) Surgical pathology of the uterine corpus. Saunders, Philadelphia
Higgs WR, Mocega EE, Jordan PH (1973) Malignant mixed tumor of the gallbladder. 32:471–475
Kempson RL, Bari W (1970) Uterine sarcomas. Classification, diagnosis and prognosis. Hum Pathol 1:331–349
Mansori KS, Cho SY (1980) Malignant mixed tumor of the gallbladder. Am J Clin Pathol 73:709–711
Mehrotra TN, Gupta SC, Naithani YP (1971) Carcinosarcoma of the gallbladder. J Pathol 104:145–148
Meyer RR (1920) Beitrag zur Verständigung über die Namengebung in der Geschwulstelehre. Zentrabl Allg Pathol 30:291–296
Norris HJ, Taylor HB (1966) Mesenchymal tumors of the uterus. III A clinical and pathologic study of 31 carcinosarcomas. Cancer 19:1459–1465
Palladino VS, Trousdell M (1969) Extrauterine mullerian tumors. A review of the literature and the report of a case. Cancer 23:1413–1422
Sternberg WH, Clark WH, Smith RC (1954) Malignant mixed mullerian tumors (mixed mesodermal tumor of the uterus). Study of 21 cases. Cancer 7:704–724
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Aldovini, D., Piscioli, F. & Togni, R. Primary malignant mixed mesodermal tumor of the gallbladder. Virchows Arch. A Path. Anat. and Histol. 396, 225–230 (1982). https://doi.org/10.1007/BF00431243
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DOI: https://doi.org/10.1007/BF00431243