Abstract
• Purpose: To describe patient characteristics, risk of recurrence, and survival in patients with premalignant and malignant melanocytic lesions of the conjunctiva. • Methods: In a retrospective study, 55 cases with a minimum follow-up of 10 years were reviewed. • Results: The actuarial 5-and 10-year survival rates were 86% (95% Cl: 76–96%) and 73% (95% Cl: 60–87%) respectively. The 5-year risk of local recurrence was 35% (95% Cl: 21–49%), and the 10-year risk was 43% (95% Cl: 28–58%). Primary acquired melanosis with atypia was the first manifestation in 13 cases, malignant melanoma in 42 cases. No significant difference in survival and recurrence was found between the two groups or by gender, location of primary lesion, histological characteristics, or extent of surgical procedure. A minimum incidence of 0.052 cases a year per 100000 in Denmark was calculated. • Conclusion: The results are estimated to represent a nationwide sample of patients. No prognostic factors of significance were identified.
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References
Cox DR (1972) Regression models and life tables. J Roy Statist Soc 34:187–220
Crawford JB (1980) Conjunctival melanomas: prognostic factors. A review and an analysis of a series. Trans Am Ophthalmol Soc LXXCVIII: 467–502
Folberg R, McLean IW, Zimmerman LE (1984) Conjunctival melanosis and melanoma. Ophthalmology 91: 673–678
Folberg R, McLean IW, Zimmerman LE (1985) Malignant melanoma of the conjunctiva. Hum Pathol 16: 136–143
Fuchs U, Kivelä T, Liesto K, Tarkkanen A (1989) Prognosis of conjunctival melanomas in relation to histopathological features. Br J Cancer 59: 261–267
Jay B (1965) Naevi and melanomata of the conjunctiva. Br J Ophthalmol 49:169–204
Jeffrey IJM, Lucas DR, McEwan C, Lee WR (1986) Malignant melanoma of the conjunctiva. Histopathology 10: 363–378
Jensen OA (1962) Xeroderma pigmentosum observed in a Greenlander. Acta Ophthalmol 40:96–103
Liesegang TJ, Campbell RJ (1980) Mayo Clinic experience with conjunctival melanomas. Arch Ophthalmol 98: 1385–1389
Lommatzsch PK, Lommatzsch RE, Kirsch I, Fuhrmann (1990) Therapeutic outcome' of patients suffering from malignant melanomas of the conjunctiva. Br J Ophthalmol 74: 615–619
Paridaens ADA, Minassian DC, McCartney ACE, Hungerford JL (1994) Prognostic factors in primary malignant melanoma of the conjunctiva: a clinicopathological study of 256 cases. Br J Ophthalmol 78: 252–259
Potter PD, Shields CL, Shields JA, Menduke H (1993) Clinical predictive factors for development of recurrence and metastasis in conjunctival melanoma: a review of 68 cases. Br J Ophthalmol 77: 624–630
Seregard S, Kock E (1992) Conjunctival malignant melanoma in Sweden 1969–91. Acta Ophthalmol 70: 289–296
Silvers DN, Jacobiec FA, Freeman TR, Lefkowitch JH, Elie RC, et al. (1978) Melanoma of the conjunctiva: a clinicopathologic study. In: Jacobiec FA (ed) Ocular and adnexal tumors. Aesculapius, Birmingham, Ala, pp 583–599
Stefani FH (1986) A prognostic index for patients with malignant melanoma of the conjunctiva. Graefe's Arch Clin Exp Ophthalmol 224: 580–582
Wolff-Rouendaal D de, Oosterhuis JA (1983) Conjunctival melanomas in the Netherlands. Doc Ophthalmol 56: 49–54
Yanoff M (1975) Ocular pathology. Harper & Row, New York, p 635
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Norregaard, J.C., Gerner, N., Jensen, O.A. et al. Malignant melanoma of the conjunctiva: occurrence and survival following surgery and radiotherapy in a Danish population. Graefe's Arch Clin Exp Ophthalmol 234, 569–572 (1996). https://doi.org/10.1007/BF00448801
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DOI: https://doi.org/10.1007/BF00448801