Abstract
The discovery of a third phosphoglucomutase locus (Pgm-3) in the house mouse is reported. Three alleles are recognized on the basis of differences in electrophoretic mobility and enzymatic activity. Pgm-3 a (fast mobility and high activity) is present in inbred strain C57BL/10J and 24 other strains; Pgm-3 b (slow mobility and high activity) is present in LP/Pas and six other strains; and Pgm-3 c (no detectable activity in any tissue tested) is present in strain DBA/2J and 14 other strains. Seventy-four recombinant inbred strains derived from progenitors that differed at Pgm-3 were used to study genic linkage. Pgm-3 is on chromosome 9 and is linked to Sep-1, d, Mod-1, and Ltw-3. Gene order and recombination frequencies are estimated as d 3.8±1.8% Pgm-3 2.3±1.2% Mod-1. Substrate specificities and cofactor requirements show that mouse Pgm-1 is homologous with human Pgm-2, mouse Pgm-2 with human Pgm-1, and mouse Pgm-3 with human Pgm-3.
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This research was supported in part by NIH Research Grant GM18684 from the National Institute of General Medical Sciences to B.A.T. and by grants from NIH A105531-02 and the Volkswagon Foundation to Jan Klein. J.H.N. was a recipient of a Fellowship from the Max-Planck-Gesellschaft, Munich. G.S. and J.K. were supported by funds from the Deutsche Forschungsgemeinschaft.
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Nadeau, J.H., Kömpf, J., Siebert, G. et al. Linkage of Pgm-3 in the house mouse and homologies of three phosphoglucomutase loci in mouse and man. Biochem Genet 19, 465–474 (1981). https://doi.org/10.1007/BF00484619
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DOI: https://doi.org/10.1007/BF00484619