Summary
50 mg/kg body weight of di-ethyl-nitrosamine was administered subcutaneously to 100 female and male O-20-mice once or twice weekly over a period of 4 weeks. Beside the well-known changes of the liver an increase of the rate of lung adenomas at significantly shortened latency period could be observed.
Zusammenfassung
100 weibliche und männliche O-20-Mäuse erhielten ein-bzw. zweimal wöchentlich 50 mg/kg KG Diäthylnitrosamin subcutan über 4 Wochen. Neben den bekannten Leberveränderungen zeigte sich die Zunahme der Lungenadenomrate bei erheblich verkürzter Latenzzeit.
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Hilfrich, J., Althoff, J. & Mohr, U. Untersuchungen zur Stimulation der Lungentumorrate durch Diäthylnitrosamin bei O-20-Mäusen. Z Krebs-forsch 75, 240–242 (1971). https://doi.org/10.1007/BF00524521
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DOI: https://doi.org/10.1007/BF00524521