Summary
The pharmacokinetics of cefoperazone after i.p. and/or i.v. administration were studied in 12 CAPD patients. After i.v. injection, the plasma half-life was 2.65±0.4 h, the total clearance amounting to 70.1±19.2 ml/min. Peritoneal clearance was calculated to be 6.9±1 ml/min. After peritoneal instillation, the bioavailability was 63.9±5%. After repeated i.p. administration, no accumulation of the drug in the body was observed. Thus, cefoperazone can be safely administered for the treatment of peritonitis in CAPD patients.
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Benet LZ, Galeazzi RL (1979) Non compartmental determination of the steady-state volume of distribution. J Pharm Sci 68: 1071–1074
Dayer P, Balant L, Fabre J, Rudhardt M, Allaz A-F (1981) Renal and extrarenal clearances of cefoperazone in patients with renal failure. Int J Clin Pharm Res 1: 233–244
Fabre J, Blanchard P, Rudhardt M (1977) Pharmacokinetics of ampicillin, cephalothin and doxycycline in various tissues of the rat. Chemotherapy 23: 129–141
Hodler J, Frey B, Rudhardt M, Seiler AJ (1983) Treatment of peritonitis in patients undergoing chronic ambulatory peritoneal dialysis (CAPD) by cefoperazone: clinical and pathophysiological aspects. Spitzy KH, Karrer K (eds) Proc. 13th International Congress of Chemotherapy. Egermann, Vienna, 1983
Keller E, Jansen A, Pelz K, Schollmeyer P, Hoppe-Seyler G (1983) Plasma levels of cefoperazone after intraperitoneal application. Clin Pharmacol Ther 33: 235
Wideröe T-E, Smeby LC, Berg KJ, Jörstad S, Svartas TM (1983) Intraperitoneal (125I) insulin absorption during intermittent and continuous peritoneal dialysis. Kidney Int 23: 22–28
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Hodler, J.E., Galeazzi, R.L., Frey, B. et al. Pharmacokinetics of cefoperazone in patients undergoing chronic ambulatory peritoneal dialysis: Clinical and pathophysiological implications. Eur J Clin Pharmacol 26, 609–612 (1984). https://doi.org/10.1007/BF00543494
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DOI: https://doi.org/10.1007/BF00543494