Abstract
Smooth muscles actively accumulate Cl. Abolition of the transmembrane Na gradient has been shown to lead to a passive distribution of Cl. This suggested to us that Na and Cl may move together across the smooth muscle cell membrane, Cl accumulation resulting due to [Na]i being less than [Na]o. In favour of this view are the findings that Cl uptake is reduced in Na-free medium, Na uptake is reduced in Cl-free medium, reducing [Cl]i reduces Na efflux, and increasing [Na]i increases Cl efflux.
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Axelsson, J., Holmberg, B.: The effects of K-free solution on tension development in the smooth muscle taenia coli from the guinea pig. Acta Physiol. Scand.82, 322–332 (1971)
Brading, A. F.: Analysis of the efflux of sodium, potassium and chloride ions from smooth muscle in normal and hypertonic solution. J. Physiol. (Lond.)214, 393–416 (1971)
Brading, A. F.: Sodium/sodium exchange in the smooth muscle of the guinea-pig taenia coli. J. Physiol. (Lond.)251, 79–105 (1975)
Casteels, R.: The action of ouabain on the smooth muscle of cells of the guinea-pig's taenia coli. J. Physiol. (Lond.)186, 131–142 (1966)
Casteels, R.: Calculation of the membrane potential in smooth muscle cells of the guinea-pig taenia coli by the Goldman equation. J. Physiol. (Lond.)205, 193–208 (1969)
Casteels, R.: The relation between the membrane potential and the ion distribution in smooth muscle cells. In: Smooth muscle (E. Bülbring, A. F. Brading, A. W. Jones, T. Tomita, eds.). London: Edward Arnold Ltd. 1970
Casteels, R.: The distribution of chloride ions in the smooth muscle cells of the guinea-pig's taenia coli. J. Physiol. Lond.214, 225–243 (1971)
Casteels, R., Kuriyama, H.: Membrane potential and ion content in the smooth muscle of the guinea-pig's taenia coli at different external potassium concentrations. J. Physiol. (Lond.)184, 120–130 (1966)
Droogmans, G., Casteels, R.: Membrane potential and ion transport in smooth muscle cells. In Physiology of smooth muscle (E. Bülbring, M. Shuba, eds.), New York: Raven Press 1976
Frizzell, R. A., Nellans, H. N., Rose, R. C., Markscheid-Kaspi, L., Schultz, S. G.: Intracellular Cl concentrations and influxes across the brush border of rabbit ileum. Am. J. Physiol.224, 328–337 (1973)
Frizzell, R. A., Dugas, M. C., Schultz, S. G.: Sodium chloride transport by rabbit gall bladder. Direct evidence for a coupled NaCl influx process. J. Gen. Physiol.65, 769–795 (1975)
Goodford, P. J.: Chloride content and36Cl uptake in the smooth muscle of the guinea-pig taenia coli. J. Physiol. (Lond.)170, 227–237 (1964)
Keynes, R. D.: Chloride in the squid giant axon. J. Physiol. (Lond.)169, 690–705 (1963)
Nellans, H. N., Frizzell, R. A., Schultz, S. G.: Coupled sodium-chloride influx across the brush border of rabbit ileum. Am. J. Physiol.225, 467–475 (1973)
Prosser, C. L.: Smooth muscle. Ann. Rev. Physiol.36, 503–535 (1974)
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Widdicombe, J.H., Brading, A.F. A possible role of linked Na and Cl movement in active Cl uptake in smooth muscle. Pflügers Arch. 386, 35–37 (1980). https://doi.org/10.1007/BF00584184
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DOI: https://doi.org/10.1007/BF00584184