Abstract
Confusion developed in a 44-year-old man, who had diarrhoea and weight loss for three months. Jejunal biopsy showed infiltration by PAS-positive macrophages, indicating Whipple's disease. Cranial MRI disclosed multiple lesions mainly in the white matter and grey-white matter junction better demonstrated after gadolinium injection.
Similar content being viewed by others
References
Comer GM, Brandt LJ, Abissi CJ (1983) Whipple's disease: a review. Am J Gastroenterol 78:107–114
Fleming JL, Wiesner RH, Shorter RG (1988) Whipple's disease: clinical, biochemical, and histopathologic features and assessment of treatment in 29 patients. Mayo Clin Proc 63:539–551
Dobbins WO III (1988) Whipple's disease. Mayo Clin Proc 63: 623–624
Pallis CA, Lewis PD (1980) Neurology of gastrointestinal disease. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 39. North-Holland, Amsterdam, pp 449–468
Pollock S, Lewis PD, Kendall B (1981) Whipple's disease confined to the nervous system. J Neurol Neurosurg Psychiatry 44: 1104–1109
Adams M, Rhyner PA, Day J, DeArmond S, Smuckler EA (1987) Whipple's disease confined to the central nervous system. Ann Neurol 21:104–108
Brown AP, Lane JC, Murayama S, Vollmer DG (1990) Whipple's disease presenting with isolated neurological symptoms. J Neurosurg 73:623–627
Wroe SJ, Pires M, Harding B, Youl BD, Shorvon S (1991) Whipple's disease confined to the CNS presenting with multiple intracerebral mass lesions. J Neurol Neurosurg Psychiatry 54: 989–992
Ryser RJ, Locksley RM, Eng SC, Dobbins WO III, Schoenknecht FD, Rubin CE (1984) Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood brain barrier. Gastroenterology 86:745–752
Grossman RI, Davis KR, Halperin J (1981) Cranial computed tomography in Whipple's disease. J Comput Assist Tomogr 5: 246–248
Ludwig B, Bohl J, Haferkamp G (1981) Central nervous system involvement in Whipple's disease. Neuroradiology 21:289–293
Davion T, Rosat P, Sevestre H, Desablens B, Debussche C, Delamarre J, Capron JP (1990) MR imaging of CNS relapse of Whipple disease. J Comput Assist Tomogr 14:815–817
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Erdem, E., Carlier, R., Delvalle, A. et al. Gadolinium-enhanced MRI in cerebral Whipple's disease. Neuroradiology 35, 581–583 (1993). https://doi.org/10.1007/BF00588397
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00588397