Summary
Serum digoxin levels were determined in 33 outpatients of a general practice in the countryside, on three occasions at intervals of 8 weeks. All the patients were on long term digoxin treatment, about 2 years on average. About 14 days after the first and the second visits the results of the measurements were sent to the patients, with a comment about their reliability in taking treatment according to the serum digoxin level. At the first visit half of the serum digoxin level were lower than 0.5 ng/ml; the mean serum concentration was 0.52 ng/ml. There was no correlation between serum concentration and age, dose or creatinine level; but there was with replies to the question about regularity of drug intake. The mean serum level at the second and the third visits was 0.88 ng/ml and 0.89 ng/ml, respectively. A correlation was found between the dose and the serum digoxin level. From these results it seems that compliance by the patient plays a major role in producing steady state levels of drugs.
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References
Blackwell, B.: Drug defaulting. Clin. Pharmacol. exp. Ther.13, 841–848 (1972)
Butler, V.P.: Assay of digitalis in blood. Progr. cardiovasc. Dis.14, 571–584 (1972)
Carruthers, S.G., Kelly, J.G., McDevitt, D.G.: Plasma digoxin concentrations in patients on admission to hospital. Brit. Heart J.36, 707–712 (1974)
Gundert-Remy, U., Karacsonyi, P., Remy, C., Weber, E.: Beziehungen zwischen klinischem Bild und Digoxinspiegel bei Patienten einer Allgemeinpraxis. Verh. dtsch. Ges. Inn. Med.80, 1530–1533 (1974)
Ochs, H., Bodem, G., Dengler, H.J.: Die biologische Verfügbarkeit von Digoxin aus Kombinationspräparaten. Klin. Wschr.52, 637–639 (1974)
Porter, A.M.W.: Drug defaulting in a general practice. Brit. med. J.1969 I, 218–222
Smith, T.W., Butler, V.P., Haber, E.: Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. New Engl. J. Med.281, 1212–1216 (1969)
Weintraub, M., Au, W.Y., Lasagna, L.: Compliance as a determinant of serum digoxin concentration. J. Amer. med. Ass.224, 481–485 (1973)
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Dedicated to Professor Dr. R. Aschenbrenner on the occasion of his 70th birthday
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Gundert-Remy, U., Remy, C. & Weber, E. Serum digoxin levels in patients of a general practice in Germany. Eur J Clin Pharmacol 10, 97–100 (1976). https://doi.org/10.1007/BF00609466
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DOI: https://doi.org/10.1007/BF00609466