Summary
Changes occurring in serotonin neurons during hyperthermia and hyperthermia-induced convulsions were examined by quantiative immunohistochemistry. A marked increase in serotonin immunoreactivity was observed at the rostral and intermediate levels of the neostriatum of mice kept at high temperatures with no convulsions, and a significant reduction in serotonin immunoreactivity was verified throughout the neostiatum of mice which had hyperthermia-induced seizures. These results suggest that serotonin neurons change significantly during thermal stress and seizures, and that regional analysis is essential for an understanding of the role of serotonin neurons.
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Takeuchi, Y., Fujiwara, K., Sato, N. et al. Further confirmation of serotonin reduction in the neostriatum during hyperthermia-induced convulsions: a quantitative immunohistochemical study. Acta Neuropathol 77, 254–257 (1989). https://doi.org/10.1007/BF00687576
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DOI: https://doi.org/10.1007/BF00687576