Summary
The material from 100 consecutive aortic and mitral valve operations has been studied histologically with particular reference to the presence of amyloid deposits. Sixty seven per cent were positive (aortic 88%, mitral 45%).
The simultaneous occurrence of calcification of the valves and amyloid degeneration as well as of calcification and hyalinization was significant. Similarly there was significantly more amyloid in the older age groups, as well as a significant correlation between the degree of hyalinization of the valve and amyloid.]
Thirty-two patients had previously suffered from rheumatic fever. The heart valves of these patients did not differ histologically from the others, whereas significantly more amyloid was observed in the stenotic mitral valves than in the mitral valves which were insufficient.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bacon APC, Matthews MB (1959). Congenital bicuspid aortic valves and the aetiology of isolated aortic valvular stenosis. Q J Med 28:545–561
Campbell M (1968). Calcefic aortic stenosis and congenital bicuspid aortic valves. Brit Heart J 30:606–616
Cathart ES, Mullarkey M, Cohen AS (1970). Amyloidosis: An expression of immunological tolerance? Lancet 2:639–640
Cooper JH (1983). Localized dystrophic amyloidosis of heart valves. Hum. Pathol. 14:649–653
Dahlin DC, Edwards JE (1949). Amyloid localized in the heart. Proceedings of the Staff Meeting of the Mayo Clinics 24:89–98
David R, Buchner A (1978). Amyloid stroma in a tubular carcinoma of the palatal salivary gland. A histochemical and ultrastructural study. Cancer 41:1836–1844
Falk E, Ladefoged C, Christensen HE (1981). Amyloid deposits in calcified aortic valves. Acta Pahtol Microbiol. Scand. Sect A 89:23–26
Frederiksen T, Gøtzsche H, Harboe N, Kiaer W, Mellemgård K (1962). Familial primary amyloidosis with severe amyloid heart disease. Am J Med 33:328–348
Goffin Y (1980). Microscopic amyloid deposits in the heart valves: A common local complication of chronic damage and scarring. J Clin Pathol 33:262–268
Iwata T, Nakamura H, Nagasawa T, Kamel T, Fujihare S, Yokota T, Uchino F (1982). Amyloid deposits in heart valves. Acta Pathol Jpn 32 (1):23–29
Kann G (1922). Ein Fall von isolierter Amyloidose des Herzens. Virchows Arch [Pathol Anat] 237:22–31
Kim KM, Valigorsky JM, Mergner WF, Jones RT, Pendergrass RF, Trump BF (1976). Aging canges in the human aortic valve in relation to dystrophic calcification. Hum Pathol 7:47–60
Kitchin A, Turner R (1967). Calcification of the mitral valve. Brit Heart J 29:137–161
Lachman AS, Roberts WC (1978). Calcific Deposits in stenotic mitral valves. Circulation 57:808–815
Linder E, Lehto V-P, Virtanen I (1979). Amyloidlike green birefringence in cytoskeletal 10 nm filaments after staining with Congo red. Acta Pathol Microbiol. Scand. Sect. A 87:299–306
Lindsay S (1946). The heart in primary systemic amyloidosis. Am Heart J 32:419–437
Maury CPJ, Teppo AM (1982). Mechanism of reduced amyloid-A-degrading activity in serum of patients with secondary amyloidosis. Lancet II:234–236
Page DL, Weiss SW, Eggleston JC (1975). Ultrastructural study of amyloid material in the calcifying epithelial odontogenic tumour. Cancer 36:1426–1435
Pomerance A (1966). The pathology of senile cardiac amyloidosis. J Pahtol Bacteniol 91:357–367
Pomerance A (1972). Pathogenesis of aortic stenosis and its relation to age. Brit Heart J 34:569–574
Pomerance A (1977). In: Sommers SC, Rosen PP (eds.). Acquired nonrheumatic valvular and endocaridal pathology, Pathology Annual, Part 2, vol. 12, p 151–187
Puchtler H, Sweet F, Levine M (1962). On the binding of Congo red by amyloid. J Histochem Cytochem 10:355–364
Ranløv P, Pindborg JJ (1966). The amyloid nature of the homogeneous substance in the calcifying epithelial odontogenic tumour. Acta Pathol microbiol Scand 68:169–174
Roberts W (1970). The structure of the aortic valve in clinically isolated aortic stenosis. Circulation 42:91–97
Schwartz P (1970) In: Amyloidosis. Cause and manifestation of senile deterioration. Thomas, Springfield. p. 80
Sell S, Scully RE (1965). Aging changes in the aortic and mitral valves. Am J Pathol 46:345–365
Shirahama T, Cohen AS (1967). High resolution electron microscopic analysis of the amyloid fibril. J Cell Biol 33:679–708
Störkel S, Schneider H-M, Thoenes W (1983). Manifestation and ultrastructural typing of amyloid deposits in the heart. Virchows Arch (Pathol Anat) 401:185–201
Symmers WStC (1956). Primary amyloidosis: A Review. J Clin Pathol 9:187–211
Virchow Rud (1857). Neue Beobachtungen über Amyloide Degeneration. Archiv für Pathologische Anatomie und Physiologi 11:188–189
Westermark P, Natvig JB, Johansson B (1977). Characterization of an amyloid fibril protein from senile cardiac amyloid. J Exp Med 146:631–636
Westermark P, Johansson B, Natvig JB (1979). Senile cardiac amyloidosis: Evidence of two different amyloid substances in the ageing heart. Scand J Immunol 10:303–308
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ladefoged, C., Rohr, N. Amyloid deposits in aortic and mitral valves. Vichows Archiv A Pathol Anat 404, 301–312 (1984). https://doi.org/10.1007/BF00694895
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00694895