Skip to main content
Log in

Arterial calcification in diabetics

  • Published:
Virchows Archiv A Aims and scope Submit manuscript

Summary

Calcification of the media of the arteries of the lower limbs, giving a linear type of calcification roentgenologically is typical for diabetic arteriosclerosis. Spotty calcification of the arteries of the lower extremity, which histologically is found in the intima, is also seen a little more often in diabetics with gangrene. There are no major differences between the other histological vascular structures of diabetics and arteriosclerotics. Maximal stenosis of the lumen is found more peripherally in diabetics than in persons with normal carbohydrate metabolism. The results favour the idea of predominant femoropopliteal occlusion in arteriosclerosis and popliteal-tibial occlusion in diabetics.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Barth D, Uhlmann M (1979) Verkalkte Arterien der unteren Extremitäten bei diabetischer und arteriosklerotischer Gangrän. Med Dipl Arbeit, Leipzig

  • Bibergeil H, Michaelis D (1983) Zur Epidermologie und Ätiopathogenese der Arteriosklerose (Makroangiopathie) bei Diabetes mellitus. Dtsch. Ges Wesen 38:89–95

    Google Scholar 

  • Bloodworth JMB (1968) Diabetes mellitus. Extrapancreatic pathology. In: Bloodworth JMB jr., (ed) Endocrine Pathology, Baltimore: Williams and Wilkins 1968

    Google Scholar 

  • Christensen NJ (1968) Muscle blood flow, measured by xenon 133 and vascular calcification in diabetics. Acta Med Scand 183:449–454

    Google Scholar 

  • Dziedzic-Goclawska A, Fuchs U, Krautschick I, Ostrowski K, Stachowicz W, Michalik J (1984) Crystallinity of mineral deposited in arterial walls in the course of arteriosclerosis in diabetics and in patients with normal carbohydrate metabolism. Bas Appl Histochem 28:21–28

    Google Scholar 

  • Ellenberg M (1973) Diabetic foot. New York State J Med 73:2778–2785

    Google Scholar 

  • Ferrier TM (1964) Radiologically demonstrable arterial calcification in diabetes mellitus. Aust Ann Med 13:222–228

    Google Scholar 

  • Fleischhauer I, Frank T, Hollmann P, Weber A (1979) Die Verkalkung der arteriellen Gefäßwand bei Diabetikern und Stoffwechselgesunden: Quantitative radiologische und chemische Analyse. Med Dipl Arbeit Leipzig

  • Ganda OMP (1980) Pathogenesis of macrovascular disease in the human diabetic. Diabetes 29:931–942

    Google Scholar 

  • Glagoiev AA (1976) Zit n Gröbler, Kleinteich, Schickedanz (1976)

  • Gröbler B, B Kleinteich, H Schickedanz (1976) Über die Bestimmung des statistischen Fehlers bei der Treffermethode. Z mikroskop anat Forsch 90:1137–1144

    Google Scholar 

  • Gendre P, Tingaud R (1974) Ultrastructure of the human arterial wall in diabetic patients. J Cardiovasc Surg 15:21–32

    Google Scholar 

  • Haimovici H (1968) Patterns of arteriosclerotic lesions of the lower extremity. Ann NY Acad Sci 149:997–1021

    Google Scholar 

  • Hevelke G (1959) Angiochemische Gefäßveränderungen bei Diabetes mellitus. In: Oberdisse K, Jahnke K (Hrsg) Diabetes mellitus, Thieme, Stuttgart pp 93–98

    Google Scholar 

  • Jarrett RJ, Keen R, Chakrabarti (1982) Diabetes, hyperglycaemia and arterial disease. In: Keen H, Jarrett J Complications of diabetes. 2nd ed., Arnhold, London pp 179–203

    Google Scholar 

  • Jarrett RJ (1984) Type 2 (non insulin dependent) diabetes mellitus and coronary heart disease - chicken, egg or neither? Diabetologia 26:99–102

    Google Scholar 

  • Kunz J (1975) Pathologie der Arterienwand mit besonderer Berücksichtigung der Glykosaminoglykane. Berlin Volk u. Gesundheit

    Google Scholar 

  • Ledet T (1968) Histological and histochemical changes in the coronary arteries of old diabetic patients. Diabetologia 4:268–272

    Google Scholar 

  • Ledet T, Fischer-Dzoga K, Wissler RW (1974) Diabetic macroangiopathy: in vitro study of the proliferation of the aortic smooth muscle cells. Am J Pathol 74:50a

    Google Scholar 

  • Ledet T, Fischer-Dzoga K, Wissler RW (1976) Growth of rabbit aortic smooth muscle cells cultured in media containing diabetic and hyperlipidemic serum. Diabetes 25:207–215

    Google Scholar 

  • Ledet T, Vuust J (1980) Arterial procollagen type I, type III and Fibronectin. Diabetes 29:964–970

    Google Scholar 

  • Lieberwirth A (1981) Quantitative morphometrische Untersuchungen an Arterien der unteren Extremitäten bei diabetischer und arteriosklerotischer Gangrän. Med Dipl Arbeit Leipzig

  • Lindbom Å (1950) Arteriosclerosis and arterial thrombosis in the lower limbs. Acta Radiol Suppl 80:38–48

    Google Scholar 

  • Lundbaek K (1977) Diabetische Angiopathie. Münch Med Wochenschr 119:647–654

    Google Scholar 

  • Lundbaek K, Posborg-Petersen V (1953) Lipid composition of diabetic and non diabetic coronary arteries. Acta Med Scand 144:354–359

    Google Scholar 

  • Meyer WW (1974) Einführung in die Pathomorphologie der Arterien In: Heberer G, Rau G u. W. Schoop (Hrsg) Angiologie. 2. Aufl. Thieme, Stuttgart pp 54–103

    Google Scholar 

  • Neubauer B (1971) A quantitative study of peripheral calcification and glucose tolerance in elderly diabetics and non diabetics. Diabetologia 7:409–413

    Google Scholar 

  • Schadt DC, Hines jr., EA, Juergens J, Barker NW (1961) Chronic arteriosclerotic occlusion of the femoral artery. J Am Med Ass 175:937–940

    Google Scholar 

  • Randerath E, Diezel PB (1959) Morphologische Pathologie der extrarenalen Angiopathie beim Diabetes mellitus. In: Oberdisse K, Jahnke K: Diabetes mellitus, Thieme, Stuttgart pp 54–60

    Google Scholar 

  • Reinknecht C (1981) Untersuchungen an Arterien bei Diabetikern und Stoffwechselgesunden mit der Glagolev'schen Treffermethode. Med Dipl Arbeit, Leipzig

  • Rosen H, Friedmann SA, Raizner AE, Gerstmann K (1972) Azotemic arteriopathy. Am Heart J 84:250–255

    Google Scholar 

  • Seldinger SJ (1964) Arteries of the extremities. In: Handbuch der medizinischen Radiologie, pp. 400–472 Bd. X., Tl 3, Springer, Berlin, Göttingen, Heidelberg, New York

    Google Scholar 

  • Strandness DE jr., Priest RE, Gibbons GE (1964) Combined clinical and pathologic study of diabetic and non-diabetic peripheral arterial disease. Diabetes 13:366–372

    Google Scholar 

  • Weibel ER, Kistler GS, Scherle WF (1966) Practical stereological methods for morphometric cytology. J Cell Biol 30:23–38

    Google Scholar 

  • Weibel ER, Elias H (1967) Quantitative methods in morphology. Springer, Berlin, Heidelberg, New York

    Google Scholar 

  • Wissler RW (1976) Abnormalities of the arterial wall and its metabolism in atherogenesis. Progr Cardiovasc Dis 18:341–369

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

The findings reported in this paper are based on the First Degree Thesis of Dietlinde Barth and Martina Uhlmann (1979), Isolde Fleischhauer, T. Frank, Petra Hollmann, A. Weber (1979), Angela Lieberwirth (1981) and C. Reinknecht (1981)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fuchs, U., Caffier, P., Schulz, H.G. et al. Arterial calcification in diabetics. Vichows Archiv A Pathol Anat 407, 431–439 (1985). https://doi.org/10.1007/BF00709989

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00709989

Key words

Navigation