Abstract
In rabbits with experimental hypothyroidism the ability of the liver mitochondria to carry out oxidative phosphorylation was undisturbed after intravenous injection of diphtheria toxin. In rabbits with experimental hyperthyroidism, the sensitivity of the liver mitochondria to the uncoupling action of diphtheria toxin was sharply increased. It is postulated that the endocrine function of the thyroid gland plays an essential role in the uncoupling action of diphtheria toxin on oxidative phosphorylation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
L. I. Niselovskaya and E. M. Paderina, Vopr. Med. Khim., No. 3, 256 (1963).
G. I. Medvedeva, Biokhimiya, No. 4, 741 (1969).
G. I. Medvedeva and L. I. Niselovskaya, Byull. Éksp. Biol. Med., No. 8, 42 (1973).
G. I. Medvedeva and L. I. Niselovskaya, Probl. Éndokrinol., No. 4, 63 (1974).
E. L. Hoch, J. Biol. Chem.,241, 524 (1966).
Additional information
Deceased
Rights and permissions
About this article
Cite this article
Medvedeva, G.M., Niselovskaya, L.I. Role of thyroid hormones in the mechanism of action of diphtheria toxin on oxidative phosphorylation in rabbit liver mitochondria. Bull Exp Biol Med 81, 513–515 (1976). https://doi.org/10.1007/BF00797554
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00797554