Abstract
The aim was to examine the influence of the independent increase of aortic wall characteristics from vascular resistance on global left ventricular (LV) function in intact hearts. In 11 anesthetized dogs, aortic stiffness was increased by a constriction of the thoracic aorta using a stiff tube, and then, in nine dogs, total systemic resistance (TSR) was increased by an infusion of angiotensin II. During the above procedures, aortic input impedance and LV diemnsion were measured. Aortic input impedance spectra revealed the steady increase in the moduli at high frequencies by aortic constriction, indicating the increase in aortic stiffness. At the stage of increased aortic characteristic impedance (Zc) (134% of control) without a change in TSR, both LV end-diastolic diameter (LVEDD, 99%, p<0.01) and stroke volume (SV, 95%, p<0.01) decreased significantly without a change in LV end-systolic diameter (LVESD). During the increase in TSR produced by angiotensin II (128% of control) without a change in Zc, LVEDD tended to increase and LVESD significantly increased (103%, p<0.01), associated with a decrease in SV (94%, p<0.01). LV systolic mean wall stress was increased by angiotensin II (118%, p<0.01), whereas it was unchanged by aortic constriction. In conclusion, the isolated increase in aortic stiffness without a change in TSR was associated with a reduction in LV preload and SV.
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References
Baez S, Laidlaw Z, Orkin LR (1974) Localization and measurement of microvascular and microcirculatory responses to venous pressure elevation in the rat heart. Blood Vessel 11: 260–276
Baez S, Feldman SM, Gootman PM (1977) Central neural influence on precapillary microvessels and sphinter. Am J Physiol 233: 141–147
Downing S, Sonnenblick EH (1963) Effects of continuous administration of angiotensin on ventricular performance. J Appl Physiol 18: 585–592
Dujardin JP, Stone DN (1981) Characteristic impedance of the proximal aorta determined in the time and frequency domein: a comparison. Med & Biol Eng & Comput 19: 565–568
Elzinga G, Westerhof N (1973) Pressure and flow generated by the left ventricule against different impedances. Circ Res 32: 178–186
Guyton AC, Jones CE, Coleman TG (1973) Cardiac output and its regulation. Circulatory Physiology, WB Saunders, Philadelphia
Henrikson O, Amtorp O, Faris I, Agerskov K (1983) Evidence for a local sympathetic venoarteriolar “reflex” in the dog hindleg. Circ Res 52: 534–542
Heyndricks GR, Boettcher DH, Vatner SF (1976) Effects of angiotensin, vasopressin, and methoxamine on cardiac function and blood flow distribution in conscious dogs. Am J Physiol 231: 1579–1587
Hittinger L, Shannon RP, Kohin S, Manders WT, Kelly P, Vatner SF (1990) Exercise-induced subendocardial dysfunction in dogs with left ventricular hypertrophy. Circ Res 66: 329–343
Kanazawa M, Shirato K, Ishikawa T, Nakajima T, Haneda T, Takishima T (1983) The effect of pericardium on the end-systolic pressuresegment length relationship in canine left ventricule in acute volume overload. Circulation 68: 1290–1298
Kelly RP, Tunin R, Kass DA (1992) Effect of reduced aortic compliance on cardiac efficiency and contractile function of in situ canine left ventricle. Circ Res 71: 490–502
Kohno M, Matsuzaki M, Ozaki M, Yano M, Katayama K, Fujii T, Kohtohu S, Ohtani N, Tateno S, Sakai H, Kusukawa R (1988) Influence of acute increase in aortic impedance on left ventricular regional wall motion during early ejection period. IEEE Engineering in Medicine & Biology Society 10th Annual International Conference: 249–251
Kumada T, Karliner H, Pouleur H, Gallagher KP, Shirato K, Ross J Jr (1979) Effect of coronary occlusion on early ventricular diastolic events in conscious dogs. Am J Physiol 237: 542–549
Latson TW (1987) The effects of finite wave velocity and discrete reflections on ventricular loading. In: Yin FCP (Eds) Ventricular/Vascular Coupling, Springer-Verlag, New York: 115–139
Lee J, Tajimi T, Patritti J, Ross J Jr (1986) Preload reserve and mechanism of afterload mismatch in normal conscious dogs. Am J Physiol 250: 464–473
Lee RW, Lancaster LD, Bucky D, Goldman S (1987) Peripheral cirenlators control of preload-afterload mismatch with angiotensin in dogs. Am J Physiol 253: 126–132
Maughan WL, Sunagawa K, Burkhoff D, Sagawa K (1984) Effect of arterial impedance changes on the end-systolic pressure-volume relation. Circ Res 54: 595–602
Pouleur H, Covell JW, Ross J Jr (1979) Effects of alterations in aortic input impedance on force-velocity-length relationship in the intact canine heart. Circ Res 45: 126–135
Rankin JS, McHale PA, Arentzen CE, Ling D, Greenfield Jr JC, Anderson RW (1976) The three-dimensional dynamic geometry of the left ventricle in the conscious dog. Circ Res 39: 304–313
Ross J Jr, Sonnenblick EH, Covell JW (1967) The architecture of the heart in systole and diastole. Technique of rapid fixation and analysis of left ventricular geometry. Circ Res 21: 409–421
Sunagawa K, Maughan WL, Sawawa K (1985) Stroke volume effect of changing arterial input impedance over selected frequency ranges. Am J Physiol 248: 477–484
Urschel CW, Covell JW, Sonnenblick HE, Ross J Jr, Braunwald EH (1968) Effects of decreased aortic compliance on performance of the left ventricle. Am J Physiol 214: 298–304
Yano M, Kumada K, Matsuzaki M, Kohno M, Hiro T, Kohtoku S, Miura T, Katayama K, Ozaki M, Kusukawa R (1989) Effect of diltiazem on aortic pressure-diameter relationship in dogs. Am J Physiol 256: 1580–1587
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Yano, M., Kohno, M., Konishi, M. et al. Effect of aortic impedance on preload-afterload mismatch in canine hearts in situ. Basic Res Cardiol 92, 115–122 (1997). https://doi.org/10.1007/BF00805572
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DOI: https://doi.org/10.1007/BF00805572