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Beta-particle dosimetry in radiation synovectomy

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Abstract

Beta-particle dosimetry of various radionuclides used in the treatment of rheumatoid arthritis was estimated using Monte Carlo radiation transport simulation coupled with experiments using reactor-produced radionuclides and radiachromic film dosimeters inserted into joint phantoms and the knees of cadavers. Results are presented as absorbed dose factors (cGy-cm2/MBq-s) versus depth in a mathematical model of the rheumatoid joint which includes regions of bone, articular cartilage, joint capsule, and tissue (synovium) found in all synovial joints. The factors can be used to estimate absorbed dose and dose rate distributions in treated joints. In particular, guidance is provided for those interested in (a) a given radionuclide's therapeutic range, (b) the amount of radioactivity to administer on a case-by-case basis, (c) the expected therapeutic dose to synovium, and (d) the radiation dose imparted to other, nontarget components in the joint, including bone and articular cartilage.

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Author notes

  1. L. S. Johnson

    Present address: Department of Radiation and Cellular Oncology, University of Chicago Medical Center, 5841 S. Maryland Avenue MC0085, 60637, Chicago, IL, USA

Authors and Affiliations

  1. Department of Nuclear Engineering and Whitaker College of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 02139, Cambridge, MA, USA

    L. S. Johnson & J. C. Yanch

  2. Department of Orthopedic Surgery, Brigham and Women's Hospital, 75 Francis Street, 02115, Boston, MA, USA

    S. Shortkroff, C. L. Barnes, A. I. Spitzere & C. B. Sledge

Authors
  1. L. S. Johnson
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  2. J. C. Yanch
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  3. S. Shortkroff
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  4. C. L. Barnes
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  5. A. I. Spitzere
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  6. C. B. Sledge
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Johnson, L.S., Yanch, J.C., Shortkroff, S. et al. Beta-particle dosimetry in radiation synovectomy. Eur J Nucl Med 22, 977–988 (1995). https://doi.org/10.1007/BF00808408

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  • DOI: https://doi.org/10.1007/BF00808408

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