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Role of T- and B-lymphocytes in heterogeneity of cell-mediated reactions to bacterial antigens in man

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Blood leukocytes from 30 patients with allergy to tuberculin and bacterial antigens were treated with antithymus (ATS) or anti-immunoglobulin serum (AIGS), after which the leukocyte migration inhibition (LMI) test was carried out with these antigens. ATS abolished LMI by tuberculin and sometimes by bacterial antigens (staphylococcal, streptococcal, etc.). AIGS frequently abolished LMI caused by bacterial antigens but not by tuberculin. In other cases treatment with any serum abolished LMI by antigens or, conversely, it was abolished only by treatment with both antisera in turn. The type of lymphocytes (T or B) determining the reaction to the same antigen in the secondary immune response differed in different patients and also differed in the same patient for different antigens. Five types of interaction between lymphocytes and antigen in the LMI test were distinguished.

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Authors
  1. D. K. Novikov
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  2. V. I. Novikova
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Novikov, D.K., Novikova, V.I. Role of T- and B-lymphocytes in heterogeneity of cell-mediated reactions to bacterial antigens in man. Bull Exp Biol Med 88, 1452–1455 (1979). https://doi.org/10.1007/BF00830360

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  • DOI: https://doi.org/10.1007/BF00830360

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