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Catecholamines induce alterations of distribution and activity of human natural killer (NK) cells

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Abstract

Catecholamines have been suggested to be responsible for altered cellular immunity after stress. This study was performed to determine the effects of adrenaline and noradrenaline on lymphocyte subpopulations and NK cell functions. Subjects were given a subcutaneous injection of either NaCl, adrenaline (5 µg/kg), or noradrenaline (10 µg/kg). Catecholamine concentrations, subsets of peripheral blood lymphocytes, NK activity, and antibody-dependent cellular cytotoxicity (ADCC) were analyzed before (baseline) and 5, 15, 30, 60, and 120 min after injection. There were no differences between groups in the distribution of CD2+ and CD8+ lymphocytes over time. However, CD3+ and CD4+ T cells decreased significantly 5 to 60 min after injection of adrenaline. In contrast, NK cell numbers (CD16+, CD56+) increased significantly 5 min after injection of adrenaline and noradrenaline, reached the highest values 15 to 30 min postinjection, and subsequently declined to baseline values 60 (noradrenaline) and 120 (adrenaline) min, respectively, after injection. Similar alterations for NK activity and ADCC were observed after administration of both catecholamines. These data suggest that both sympatheticadrenal hormones are similarly potent modulators of natural immunity and provide further evidence that catecholamines might be responsible for the observed alterations in immune functions after phases of acute stress.

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Authors and Affiliations

  1. Division of Medical Psychology, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, 30625, Hannover, Germany

    Manfred Schedlowski & Uwe Tewes

  2. Division of Immunology, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, 30625, Hannover, Germany

    Anette Falk, Roland Jacobs & Reinhold E. Schmidt

  3. Division of Endocrinology, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, 30625, Hannover, Germany

    Axel Rohne & Thomas O. F. Wagner

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  1. Manfred Schedlowski
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  2. Anette Falk
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Schedlowski, M., Falk, A., Rohne, A. et al. Catecholamines induce alterations of distribution and activity of human natural killer (NK) cells. J Clin Immunol 13, 344–351 (1993). https://doi.org/10.1007/BF00920243

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